Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)
1_MALVA 6_ SVRVP 11_ ARVLL 16_ RAGAR 21_ LPGAA 26_ LGRTE 31_ RAAGG 36_ GDGAR 41_ RFGSQ 46_ RVLVE 51_ PDAGA 56_ GVAVM 61_ KFKNP 66_ PVNSL 71_ SLEFL 76_ TELVI 81_ SLEKL 86_ ENDKS 91_ FRGVI 96_ LTSDR 101_ PGVFS 106_ AGLDL 111_ TEMCG 116_ RSPAH 121_ YAGYW 126_ KAVQE 131_ LWLRL 136_ YQSNL 141_ VLVSA 146_ INGAC 151_ PAGGC 156_ LVALT 161_ CDYRI 166_ LADNP 171_ RYCIG 176_ LNETQ 181_ LGIIA 186_ PFWLK 191_ DTLEN 196_ TIGHR 201_ AAERA 206_ LQLGL 211_ LFPPA 216_ EALQV 221_ GIVDQ 226_ VVPEE 231_ QVQST 236_ ALSAI 241_ AQWMA 246_ IPDHA 251_ RQLTK 256_ AMMRK 261_ ATASR 266_ LVTQR 271_ DADVQ 276_ NFVSF 281_ ISKDS 286_ IQKSL 291_ QMYLE 296_RLKEE
1: Key enzyme of fatty acid beta-oxidation (Probable). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (By similarity) (PubMed:7818490). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length (By similarity)