Agouti-signaling protein (ASP) (Agouti switch protein)
1_MDVTR 6_ LLLAT 11_ LLVFL 16_ CFFTA 21_ NSHLP 26_ PEEKL 31_ RDDRS 36_ LRSNS 41_ SVNLL 46_ DVPSV 51_ SIVAL 56_ NKKSK 61_ QIGRK 66_ AAEKK 71_ RSSKK 76_ EASMK 81_ KVVRP 86_ RTPLS 91_ APCVA 96_ TRNSC 101_ KPPAP 106_ ACCDP 111_ CASCQ 116_ CRFFR 121_ SACSC 126_RVLSL
1: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes