Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
1_MSQWY 6_ ELQQL 11_ DSKFL 16_ EQVHQ 21_ LYDDS 26_ FPMEI 31_ RQYLA 36_ QWLEK 41_ QDWEH 46_ AANDV 51_ SFATI 56_ RFHDL 61_ LSQLD 66_ DQYSR 71_ FSLEN 76_ NFLLQ 81_ HNIRK 86_ SKRNL 91_ QDNFQ 96_ EDPIQ 101_ MSMII 106_ YSCLK 111_ EERKI 116_ LENAQ 121_ RFNQA 126_ QSGNI 131_ QSTVM 136_ LDKQK 141_ ELDSK 146_ VRNVK 151_ DKVMC 156_ IEHEI 161_ KSLED 166_ LQDEY 171_ DFKCK 176_ TLQNR 181_ EHETN 186_ GVAKS 191_ DQKQE 196_ QLLLK 201_ KMYLM 206_ LDNKR 211_ KEVVH 216_ KIIEL 221_ LNVTE 226_ LTQNA 231_ LINDE 236_ LVEWK 241_ RRQQS 246_ ACIGG 251_ PPNAC 256_ LDQLQ 261_ NWFTI 266_ VAESL 271_ QQVRQ 276_ QLKKL 281_ EELEQ 286_ KYTYE 291_ HDPIT 296_ KNKQV 301_ LWDRT 306_ FSLFQ 311_ QLIQS 316_ SFVVE 321_ RQPCM 326_ PTHPQ 331_ RPLVL 336_ KTGVQ 341_ FTVKL 346_ RLLVK 351_ LQELN 356_ YNLKV 361_ KVLFD 366_ KDVNE 371_ RNTVK 376_ GFRKF 381_ NILGT 386_ HTKVM 391_ NMEES 396_ TNGSL 401_ AAEFR 406_ HLQLK 411_ EQKNA 416_ GTRTN 421_ EGPLI 426_ VTEEL 431_ HSLSF 436_ ETQLC 441_ QPGLV 446_ IDLET 451_ TSLPV 456_ VVISN 461_ VSQLP 466_ SGWAS 471_ ILWYN 476_ MLVAE 481_ PRNLS 486_ FFLTP 491_ PCARW 496_ AQLSE 501_ VLSWQ 506_ FSSVT 511_ KRGLN 516_ VDQLN 521_ MLGEK 526_ LLGPN 531_ ASPDG 536_ LIPWT 541_ RFCKE 546_ NINDK 551_ NFPFW 556_ LWIES 561_ ILELI 566_ KKHLL 571_ PLWND 576_ GCIMG 581_ FISKE 586_ RERAL 591_ LKDQQ 596_ PGTFL 601_ LRFSE 606_ SSREG 611_ AITFT 616_ WVERS 621_ QNGGE 626_ PDFHA 631_ VEPYT 636_ KKELS 641_ AVTFP 646_ DIIRN 651_ YKVMA 656_ AENIP 661_ ENPLK 666_ YLYPN 671_ IDKDH 676_ AFGKY 681_ YSRPK 686_ EAPEP 691_ MELDG 696_ PKGTG 701_ YIKTE 706_ LISVS 711_ EVHPS 716_ RLQTT 721_ DNLLP 726_ MSPEE 731_ FDEVS 736_ RIVGS 741_VEFDS
1: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578, PubMed:15322115, PubMed:23940278, PubMed:34508746, PubMed:35568036, PubMed:9724754). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426, PubMed:35568036). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state (PubMed:28753426, PubMed:35568036). In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state (PubMed:8156998). Becomes activated in response to KITLG/SCF and KIT signaling (PubMed:15526160). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:19088846). Following bacterial lipopolysaccharide (LPS)-induced TLR4 endocytosis, phosphorylated at Thr-749 by IKBKB which promotes binding of STAT1 to the 5'-TTTGAGGC-3' sequence in the ARID5A promoter, resulting in transcriptional activation of ARID5A and subsequent ARID5A-mediated stabilization of IL6 (PubMed:32209697). Phosphorylation at Thr-749 also promotes binding of STAT1 to the 5'-TTTGAGTC-3' sequence in the IL12B promoter and activation of IL12B transcription (PubMed:32209697). Involved in food tolerance in small intestine: associates with the Gasdermin-D, p13 cleavage product (13 kDa GSDMD) and promotes transcription of CIITA, inducing type 1 regulatory T (Tr1) cells in upper small intestine (By similarity)