Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1)
1_MQHIF 6_ AFFCT 11_ GFLGA 16_ VVGAN 21_ FPNNI 26_ QIGGL 31_ FPNQQ 36_ SQEHA 41_ AFRFA 46_ LSQLT 51_ EPPKL 56_ LPQID 61_ IVNIS 66_ DSFEM 71_ TYRFC 76_ SQFSK 81_ GVYAI 86_ FGFYE 91_ RRTVN 96_ MLTSF 101_ CGALH 106_ VCFIT 111_ PSFPV 116_ DTSNQ 121_ FVLQL 126_ RPELQ 131_ DALIS 136_ IIDHY 141_ KWQKF 146_ VYIYD 151_ ADRGL 156_ SVLQK 161_ VLDTA 166_ AEKNW 171_ QVTAV 176_ NILTT 181_ TEEGY 186_ RMLFQ 191_ DLEKK 196_ KERLV 201_ VVDCE 206_ SERLN 211_ AILGQ 216_ IIKLE 221_ KNGIG 226_ YHYIL 231_ ANLGF 236_ MDIDL 241_ NKFKE 246_ SGANV 251_ TGFQL 256_ VNYTD 261_ TIPAK 266_ IMQQW 271_ KNSDA 276_ RDHTR 281_ VDWKR 286_ PKYTS 291_ ALTYD 296_ GVKVM 301_ AEAFQ 306_ SLRRQ 311_ RIDIS 316_ RRGNA 321_ GDCLA 326_ NPAVP 331_ WGQGI 336_ DIQRA 341_ LQQVR 346_ FEGLT 351_ GNVQF 356_ NEKGR 361_ RTNYT 366_ LHVIE 371_ MKHDG 376_ IRKIG 381_ YWNED 386_ DKFVP 391_ AATDA 396_ QAGGD 401_ NSSVQ 406_ NRTYI 411_ VTTIL 416_ EDPYV 421_ MLKKN 426_ ANQFE 431_ GNDRY 436_ EGYCV 441_ ELAAE 446_ IAKHV 451_ GYSYR 456_ LEIVS 461_ DGKYG 466_ ARDPD 471_ TKAWN 476_ GMVGE 481_ LVYGR 486_ ADVAV 491_ APLTI 496_ TLVRE 501_ EVIDF 506_ SKPFM 511_ SLGIS 516_ IMIKK 521_ PQKSK 526_ PGVFS 531_ FLDPL 536_ AYEIW 541_ MCIVF 546_ AYIGV 551_ SVVLF 556_ LVSRF 561_ SPYEW 566_ HSEEF 571_ EEGRD 576_ QTTSD 581_ QSNEF 586_ GIFNS 591_ LWFSL 596_ GAFMQ 601_ QGCDI 606_ SPRSL 611_ SGRIV 616_ GGVWW 621_ FFTLI 626_ IISSY 631_ TANLA 636_ AFLTV 641_ ERMVS 646_ PIESA 651_ EDLAK 656_ QTEIA 661_ YGTLE 666_ AGSTK 671_ EFFRR 676_ SKIAV 681_ FEKMW 686_ TYMKS 691_ AEPSV 696_ FVRTT 701_ EEGMI 706_ RVRKS 711_ KGKYA 716_ YLLES 721_ TMNEY 726_ IEQRK 731_ PCDTM 736_ KVGGN 741_ LDSKG 746_ YGIAT 751_ PKGSA 756_ LRNPV 761_ NLAVL 766_ KLNEQ 771_ GLLDK 776_ LKNKW 781_ WYDKG 786_ ECGSG 791_ GGDSK 796_ DKTSA 801_ LSLSN 806_ VAGVF 811_ YILIG 816_ GLGLA 821_ MLVAL 826_ IEFCY 831_ KSRSE 836_ SKRMK 841_ GFCLI 846_ PQQSI 851_ NEAIR 856_ TSTLP 861_ RNSGA 866_ GASSG 871_ GSGEN 876_ GRVVS 881_ HDFPK 886_ SMQSI 891_ PCMSH 896_ SSGMP 901_LGATG
1: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (PubMed:21172611). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity)