Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)
1_MQKIM 6_ HISVL 11_ LSPVL 16_ WGLIF 21_ GVSSN 26_ SIQIG 31_ GLFPR 36_ GADQE 41_ YSAFR 46_ VGMVQ 51_ FSTSE 56_ FRLTP 61_ HIDNL 66_ EVANS 71_ FAVTN 76_ AFCSQ 81_ FSRGV 86_ YAIFG 91_ FYDKK 96_ SVNTI 101_ TSFCG 106_ TLHVS 111_ FITPS 116_ FPTDG 121_ THPFV 126_ IQMRP 131_ DLKGA 136_ LLSLI 141_ EYYQW 146_ DKFAY 151_ LYDSD 156_ RGLST 161_ LQAVL 166_ DSAAE 171_ KKWQV 176_ TAINV 181_ GNINN 186_ DKKDE 191_ MYRSL 196_ FQDLE 201_ LKKER 206_ RVILD 211_ CERDK 216_ VNDIV 221_ DQVIT 226_ IGKHV 231_ KGYHY 236_ IIANL 241_ GFTDG 246_ DLLKI 251_ QFGGA 256_ NVSGF 261_ QIVDY 266_ DDSLV 271_ SKFIE 276_ RWSTL 281_ EEKEY 286_ PGAHT 291_ TTIKY 296_ TSALT 301_ YDAVQ 306_ VMTEA 311_ FRNLR 316_ KQRIE 321_ ISRRG 326_ NAGDC 331_ LANPA 336_ VPWGQ 341_ GVEIE 346_ RALKQ 351_ VQVEG 356_ LSGNI 361_ KFDQN 366_ GKRIN 371_ YTINI 376_ MELKT 381_ NGPRK 386_ IGYWS 391_ EVDKM 396_ VVTLT 401_ ELPSG 406_ NDTSG 411_ LENKT 416_ VVVTT 421_ ILESP 426_ YVMMK 431_ KNHEM 436_ LEGNE 441_ RYEGY 446_ CVDLA 451_ AEIAK 456_ HCGFK 461_ YKLTI 466_ VGDGK 471_ YGARD 476_ ADTKI 481_ WNGMV 486_ GELVY 491_ GKADI 496_ AIAPL 501_ TITLV 506_ REEVI 511_ DFSKP 516_ FMSLG 521_ ISIMI 526_ KKPQK 531_ SKPGV 536_ FSFLD 541_ PLAYE 546_ IWMCI 551_ VFAYI 556_ GVSVV 561_ LFLVS 566_ RFSPY 571_ EWHTE 576_ EFEDG 581_ RETQS 586_ SESTN 591_ EFGIF 596_ NSLWF 601_ SLGAF 606_ MQQGC 611_ DISPR 616_ SLSGR 621_ IVGGV 626_ WWFFT 631_ LIIIS 636_ SYTAN 641_ LAAFL 646_ TVERM 651_ VSPIE 656_ SAEDL 661_ SKQTE 666_ IAYGT 671_ LDSGS 676_ TKEFF 681_ RRSKI 686_ AVFDK 691_ MWTYM 696_ RSAEP 701_ SVFVR 706_ TTAEG 711_ VARVR 716_ KSKGK 721_ YAYLL 726_ ESTMN 731_ EYIEQ 736_ RKPCD 741_ TMKVG 746_ GNLDS 751_ KGYGI 756_ ATPKG 761_ SSLRN 766_ AVNLA 771_ VLKLN 776_ EQGLL 781_ DKLKN 786_ KWWYD 791_ KGECG 796_ SGGGD 801_ SKEKT 806_ SALSL 811_ SNVAG 816_ VFYIL 821_ VGGLG 826_ LAMLV 831_ ALIEF 836_ CYKSR 841_ AEAKR 846_ MKVAK 851_ NAQNI 856_ NPSSS 861_ QNSQN 866_ FATYK 871_ EGYNV 876_YGIES
1: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:20614889, PubMed:31300657, PubMed:8003671). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (PubMed:14687553). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:20614889, PubMed:8003671). The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (By similarity). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)