Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3)
1_MARQK 6_ KMGQS 11_ VLRAV 16_ FFLVL 21_ GLLGH 26_ SHGGF 31_ PNTIS 36_ IGGLF 41_ MRNTV 46_ QEHSA 51_ FRFAV 56_ QLYNT 61_ NQNTT 66_ EKPFH 71_ LNYHV 76_ DHLDS 81_ SNSFS 86_ VTNAF 91_ CSQFS 96_ RGVYA 101_ IFGFY 106_ DQMSM 111_ NTLTS 116_ FCGAL 121_ HTSFV 126_ TPSFP 131_ TDADV 136_ QFVIQ 141_ MRPAL 146_ KGAIL 151_ SLLGH 156_ YKWEK 161_ FVYLY 166_ DTERG 171_ FSILQ 176_ AIMEA 181_ AVQNN 186_ WQVTA 191_ RSVGN 196_ IKDVQ 201_ EFRRI 206_ IEEMD 211_ RRQEK 216_ RYLID 221_ CEVER 226_ INTIL 231_ EQVVI 236_ LGKHS 241_ RGYHY 246_ MLANL 251_ GFTDI 256_ LLERV 261_ MHGGA 266_ NITGF 271_ QIVNN 276_ ENPMV 281_ QQFIQ 286_ RWVRL 291_ DEREF 296_ PEAKN 301_ APLKY 306_ TSALT 311_ HDAIL 316_ VIAEA 321_ FRYLR 326_ RQRVD 331_ VSRRG 336_ SAGDC 341_ LANPA 346_ VPWSQ 351_ GIDIE 356_ RALKM 361_ VQVQG 366_ MTGNI 371_ QFDTY 376_ GRRTN 381_ YTIDV 386_ YEMKV 391_ SGSRK 396_ AGYWN 401_ EYERF 406_ VPFSD 411_ QQISN 416_ DSASS 421_ ENRTI 426_ VVTTI 431_ LESPY 436_ VMYKK 441_ NHEQL 446_ EGNER 451_ YEGYC 456_ VDLAY 461_ EIAKH 466_ VRIKY 471_ KLSIV 476_ GDGKY 481_ GARDP 486_ ETKIW 491_ NGMVG 496_ ELVYG 501_ RADIA 506_ VAPLT 511_ ITLVR 516_ EEVID 521_ FSKPF 526_ MSLGI 531_ SIMIK 536_ KPQKS 541_ KPGVF 546_ SFLDP 551_ LAYEI 556_ WMCIV 561_ FAYIG 566_ VSVVL 571_ FLVSR 576_ FSPYE 581_ WHLED 586_ NNEEP 591_ RDPQS 596_ PPDPP 601_ NEFGI 606_ FNSLW 611_ FSLGA 616_ FMQQG 621_ CDISP 626_ RSLSG 631_ RIVGG 636_ VWWFF 641_ TLIII 646_ SSYTA 651_ NLAAF 656_ LTVER 661_ MVSPI 666_ ESAED 671_ LAKQT 676_ EIAYG 681_ TLDSG 686_ STKEF 691_ FRRSK 696_ IAVYE 701_ KMWSY 706_ MKSAE 711_ PSVFT 716_ KTTAD 721_ GVARV 726_ RKSKG 731_ KFAFL 736_ LESTM 741_ NEYIE 746_ QRKPC 751_ DTMKV 756_ GGNLD 761_ SKGYG 766_ VATPK 771_ GSALR 776_ NAVNL 781_ AVLKL 786_ NEQGL 791_ LDKLK 796_ NKWWY 801_ DKGEC 806_ GSGGG 811_ DSKDK 816_ TSALS 821_ LSNVA 826_ GVFYI 831_ LVGGL 836_ GLAMM 841_ VALIE 846_ FCYKS 851_ RAESK 856_ RMKLT 861_ KNTQN 866_ FKPAP 871_ ATNTQ 876_ NYATY 881_ REGYN 886_VYGTE
1: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (PubMed:17989220). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17989220). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (PubMed:21172611)