Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)
1_MADAF 6_ GDELF 11_ SVFEG 16_ DSTTA 21_ AGTKK 26_ DKEKD 31_ KGKWK 36_ GPPGS 41_ ADKAG 46_ KRFDG 51_ KLQSE 56_ STNNG 61_ KNKRD 66_ VDFEG 71_ TDEPI 76_ FGKKP 81_ RIEES 86_ ITEDL 91_ SLADL 96_ MPRVK 101_ VQSVE 106_ TVEGC 111_ THEVA 116_ LPAEE 121_ DYLPL 126_ KPRVG 131_ KAAKE 136_ YPFIL 141_ DAFQR 146_ EAIQC 151_ VDNNQ 156_ SVLVS 161_ AHTSA 166_ GKTVC 171_ AEYAI 176_ ALALR 181_ EKQRV 186_ IFTSP 191_ IKALS 196_ NQKYR 201_ EMYEE 206_ FQDVG 211_ LMTGD 216_ VTINP 221_ TASCL 226_ VMTTE 231_ ILRSM 236_ LYRGS 241_ EVMRE 246_ VAWVI 251_ FDEIH 256_ YMRDS 261_ ERGVV 266_ WEETI 271_ ILLPD 276_ NVHYV 281_ FLSAT 286_ IPNAR 291_ QFAEW 296_ ICHLH 301_ KQPCH 306_ VIYTD 311_ YRPTP 316_ LQHYI 321_ FPAGG 326_ DGLHL 331_ VVDEN 336_ GDFRE 341_ DNFNT 346_ AMQVL 351_ RDAGD 356_ LAKGD 361_ QKGRK 366_ GGTKG 371_ PSNVF 376_ KIVKM 381_ IMERN 386_ FQPVI 391_ IFSFS 396_ KKDCE 401_ AYALQ 406_ MTKLD 411_ FNTDE 416_ EKKMV 421_ EEVFS 426_ NAIDC 431_ LSDED 436_ KKLPQ 441_ VEHVL 446_ PLLKR 451_ GIGIH 456_ HGGLL 461_ PILKE 466_ TIEIL 471_ FSEGL 476_ IKALF 481_ ATETF 486_ AMGIN 491_ MPART 496_ VLFTN 501_ ARKFD 506_ GKDFR 511_ WISSG 516_ EYIQM 521_ SGRAG 526_ RRGMD 531_ DRGIV 536_ ILMVD 541_ EKMSP 546_ TIGKQ 551_ LLKGS 556_ ADPLN 561_ SAFHL 566_ TYNMV 571_ LNLLR 576_ VEEIN 581_ PEYML 586_ EKSFY 591_ QFQHY 596_ RAIPG 601_ VVEKV 606_ KNSEE 611_ QYNKI 616_ VIPNE 621_ ESVVI 626_ YYKIR 631_ QQLAK 636_ LGKEI 641_ EEYIH 646_ KPKYC 651_ LPFLQ 656_ PGRLV 661_ KVKNE 666_ GDDFG 671_ WGVVV 676_ NFSKK 681_ SNVKP 686_ NSGEL 691_ DPLYV 696_ VEVLL 701_ RCSKE 706_ SLKNS 711_ ATEAA 716_ KPAKP 721_ DEKGE 726_ MQVVP 731_ VLVHL 736_ LSAIS 741_ SVRLY 746_ IPKDL 751_ RPVDN 756_ RQSVL 761_ KSIQE 766_ VQKRF 771_ PDGIP 776_ LLDPI 781_ DDMGI 786_ QDQGL 791_ KKVIQ 796_ KVEAF 801_ EHRMY 806_ SHPLH 811_ NDPNL 816_ ETVYT 821_ LCEKK 826_ AQIAI 831_ DIKSA 836_ KRELK 841_ KARTV 846_ LQMDE 851_ LKCRK 856_ RVLRR 861_ LGFAT 866_ SSDVI 871_ EMKGR 876_ VACEI 881_ SSADE 886_ LLLTE 891_ MMFNG 896_ LFNDL 901_ SAEQA 906_ TALLS 911_ CFVFQ 916_ ENSSE 921_ MPKLT 926_ EQLAG 931_ PLRQM 936_ QECAK 941_ RIAKV 946_ SAEAK 951_ LEIDE 956_ ETYLS 961_ SFKPH 966_ LMDVV 971_ YTWAT 976_ GATFA 981_ HICKM 986_ TDVFE 991_ GSIIR 996_ CMRRL 1001_ EELLR 1006_ QMCQA 1011_ AKAIG 1016_ NTELE 1021_ NKFAE 1026_ GITKI 1031_ KRDIV 1036_FAASL
1: Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension (PubMed:27871484, PubMed:29844170, PubMed:29906447). Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT) (PubMed:21855801, PubMed:27871484, PubMed:29844170). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484, PubMed:29844170). PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand (PubMed:29844170). Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex (PubMed:29906447). Plays a role in DNA damage response (PubMed:29902117)