Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64)
1_MDSKH 6_ QCVKL 11_ NDGHF 16_ MPVLG 21_ FGTYA 26_ PPEVP 31_ RSKAL 36_ EVTKL 41_ AIEAG 46_ FRHID 51_ SAHLY 56_ NNEEQ 61_ VGLAI 66_ RSKIA 71_ DGSVK 76_ REDIF 81_ YTSKL 86_ WSTFH 91_ RPELV 96_ RPALE 101_ NSLKK 106_ AQLDY 111_ VDLYL 116_ IHSPM 121_ SLKPG 126_ EELSP 131_ TDENG 136_ KVIFD 141_ IVDLC 146_ TTWEA 151_ MEKCK 156_ DAGLA 161_ KSIGV 166_ SNFNR 171_ RQLEM 176_ ILNKP 181_ GLKYK 186_ PVCNQ 191_ VECHP 196_ YFNRS 201_ KLLDF 206_ CKSKD 211_ IVLVA 216_ YSALG 221_ SQRDK 226_ RWVDP 231_ NSPVL 236_ LEDPV 241_ LCALA 246_ KKHKR 251_ TPALI 256_ ALRYQ 261_ LQRGV 266_ VVLAK 271_ SYNEQ 276_ RIRQN 281_ VQVFE 286_ FQLTA 291_ EDMKA 296_ IDGLD 301_ RNLHY 306_ FNSDS 311_ FASHP 316_NYPYS
1: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:11165022, PubMed:14672942). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:10622721, PubMed:10998348, PubMed:11165022, PubMed:15047184, PubMed:19010934, PubMed:20036328). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10557352, PubMed:10998348, PubMed:11165022, PubMed:14672942, PubMed:7650035, PubMed:9415401). Also displays retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338)