Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
1_MPPRP 6_ SSGEL 11_ WGIHL 16_ MPPRI 21_ LVECL 26_ LPNGM 31_ IVTLE 36_ CLREA 41_ TLITI 46_ KHELF 51_ KEARK 56_ YPLHQ 61_ LLQDE 66_ SSYIF 71_ VSVTQ 76_ EAERE 81_ EFFDE 86_ TRRLC 91_ DLRLF 96_ QPFLK 101_ VIEPV 106_ GNREE 111_ KILNR 116_ EIGFA 121_ IGMPV 126_ CEFDM 131_ VKDPE 136_ VQDFR 141_ RNILN 146_ VCKEA 151_ VDLRD 156_ LNSPH 161_ SRAMY 166_ VYPPN 171_ VESSP 176_ ELPKH 181_ IYNKL 186_ DKGQI 191_ IVVIW 196_ VIVSP 201_ NNDKQ 206_ KYTLK 211_ INHDC 216_ VPEQV 221_ IAEAI 226_ RKKTR 231_ SMLLS 236_ SEQLK 241_ LCVLE 246_ YQGKY 251_ ILKVC 256_ GCDEY 261_ FLEKY 266_ PLSQY 271_ KYIRS 276_ CIMLG 281_ RMPNL 286_ MLMAK 291_ ESLYS 296_ QLPMD 301_ CFTMP 306_ SYSRR 311_ ISTAT 316_ PYMNG 321_ ETSTK 326_ SLWVI 331_ NSALR 336_ IKILC 341_ ATYVN 346_ VNIRD 351_ IDKIY 356_ VRTGI 361_ YHGGE 366_ PLCDN 371_ VNTQR 376_ VPCSN 381_ PRWNE 386_ WLNYD 391_ IYIPD 396_ LPRAA 401_ RLCLS 406_ ICSVK 411_ GRKGA 416_ KEEHC 421_ PLAWG 426_ NINLF 431_ DYTDT 436_ LVSGK 441_ MALNL 446_ WPVPH 451_ GLEDL 456_ LNPIG 461_ VTGSN 466_ PNKET 471_ PCLEL 476_ EFDWF 481_ SSVVK 486_ FPDMS 491_ VIEEH 496_ ANWSV 501_ SREAG 506_ FSYSH 511_ AGLSN 516_ RLARD 521_ NELRE 526_ NDKEQ 531_ LKAIS 536_ TRDPL 541_ SEITE 546_ QEKDF 551_ LWSHR 556_ HYCVT 561_ IPEIL 566_ PKLLL 571_ SVKWN 576_ SRDEV 581_ AQMYC 586_ LVKDW 591_ PPIKP 596_ EQAME 601_ LLDCN 606_ YPDPM 611_ VRGFA 616_ VRCLE 621_ KYLTD 626_ DKLSQ 631_ YLIQL 636_ VQVLK 641_ YEQYL 646_ DNLLV 651_ RFLLK 656_ KALTN 661_ QRIGH 666_ FFFWH 671_ LKSEM 676_ HNKTV 681_ SQRFG 686_ LLLES 691_ YCRAC 696_ GMYLK 701_ HLNRQ 706_ VEAME 711_ KLINL 716_ TDILK 721_ QEKKD 726_ ETQKV 731_ QMKFL 736_ VEQMR 741_ RPDFM 746_ DALQG 751_ FLSPL 756_ NPAHQ 761_ LGNLR 766_ LEECR 771_ IMSSA 776_ KRPLW 781_ LNWEN 786_ PDIMS 791_ ELLFQ 796_ NNEII 801_ FKNGD 806_ DLRQD 811_ MLTLQ 816_ IIRIM 821_ ENIWQ 826_ NQGLD 831_ LRMLP 836_ YGCLS 841_ IGDCV 846_ GLIEV 851_ VRNSH 856_ TIMQI 861_ QCKGG 866_ LKGAL 871_ QFNSH 876_ TLHQW 881_ LKDKN 886_ KGEIY 891_ DAAID 896_ LFTRS 901_ CAGYC 906_ VATFI 911_ LGIGD 916_ RHNSN 921_ IMVKD 926_ DGQLF 931_ HIDFG 936_ HFLDH 941_ KKKKF 946_ GYKRE 951_ RVPFV 956_ LTQDF 961_ LIVIS 966_ KGAQE 971_ CTKTR 976_ EFERF 981_ QEMCY 986_ KAYLA 991_ IRQHA 996_ NLFIN 1001_ LFSMM 1006_ LGSGM 1011_ PELQS 1016_ FDDIA 1021_ YIRKT 1026_ LALDK 1031_ TEQEA 1036_ LEYFM 1041_ KQMND 1046_ AHHGG 1051_ WTTKM 1056_ DWIFH 1061_TIKQH
1: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396, PubMed:28676499). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed:23936502, PubMed:28676499). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity)