Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)
1_MCFSF 6_ IMPPA 11_ MADIL 16_ DIWAV 21_ DSQIA 26_ SDGSI 31_ PVDFL 36_ LPTGI 41_ YIQLE 46_ VPREA 51_ TISYI 56_ KQMLW 61_ KQVHN 66_ YPMFN 71_ LLMDI 76_ DSYMF 81_ ACVNQ 86_ TAVYE 91_ ELEDE 96_ TRRLC 101_ DVRPF 106_ LPVLK 111_ LVTRS 116_ CDPGE 121_ KLDSK 126_ IGVLI 131_ GKGLH 136_ EFDSL 141_ KDPEV 146_ NEFRR 151_ KMRKF 156_ SEEKI 161_ LSLVG 166_ LSWMD 171_ WLKQT 176_ YPPEH 181_ EPSIP 186_ ENLED 191_ KLYGG 196_ KLIVA 201_ VHFEN 206_ CQDVF 211_ SFQVS 216_ PNMNP 221_ IKVNE 226_ LAIQK 231_ RLTIH 236_ GKEDE 241_ VSPYD 246_ YVLQV 251_ SGRVE 256_ YVFGD 261_ HPLIQ 266_ FQYIR 271_ NCVMN 276_ RALPH 281_ FILVE 286_ CCKIK 291_ KMYEQ 296_ EMIAI 301_ EAAIN 306_ RNSSN 311_ LPLPL 316_ PPKKT 321_ RIISH 326_ VWENN 331_ NPFQI 336_ VLVKG 341_ NKLNT 346_ EETVK 351_ VHVRA 356_ GLFHG 361_ TELLC 366_ KTIVS 371_ SEVSG 376_ KNDHI 381_ WNEPL 386_ EFDIN 391_ ICDLP 396_ RMARL 401_ CFAVY 406_ AVLDK 411_ VKTKK 416_ STKTI 421_ NPSKY 426_ QTIRK 431_ AGKVH 436_ YPVAW 441_ VNTMV 446_ FDFKG 451_ QLRTG 456_ DIILH 461_ SWSSF 466_ PDELE 471_ EMLNP 476_ MGTVQ 481_ TNPYT 486_ ENATA 491_ LHVKF 496_ PENKK 501_ QPYYY 506_ PPFDK 511_ IIEKA 516_ AEIAS 521_ SDSAN 526_ VSSRG 531_ GKKFL 536_ PVLKE 541_ ILDRD 546_ PLSQL 551_ CENEM 556_ DLIWT 561_ LRQDC 566_ REIFP 571_ QSLPK 576_ LLLSI 581_ KWNKL 586_ EDVAQ 591_ LQALL 596_ QIWPK 601_ LPPRE 606_ ALELL 611_ DFNYP 616_ DQYVR 621_ EYAVG 626_ CLRQM 631_ SDEEL 636_ SQYLL 641_ QLVQV 646_ LKYEP 651_ FLDCA 656_ LSRFL 661_ LERAL 666_ GNRRI 671_ GQFLF 676_ WHLRS 681_ EVHIP 686_ AVSVQ 691_ FGVIL 696_ EAYCR 701_ GSVGH 706_ MKVLS 711_ KQVEA 716_ LNKLK 721_ TLNSL 726_ IKLNA 731_ VKLNR 736_ AKGKE 741_ AMHTC 746_ LKQSA 751_ YREAL 756_ SDLQS 761_ PLNPC 766_ VILSE 771_ LYVEK 776_ CKYMD 781_ SKMKP 786_ LWLVY 791_ NNKVF 796_ GEDSV 801_ GVIFK 806_ NGDDL 811_ RQDML 816_ TLQML 821_ RLMDL 826_ LWKEA 831_ GLDLR 836_ MLPYG 841_ CLATG 846_ DRSGL 851_ IEVVS 856_ TSETI 861_ ADIQL 866_ NSSNV 871_ AAAAA 876_ FNKDA 881_ LLNWL 886_ KEYNS 891_ GDDLD 896_ RAIEE 901_ FTLSC 906_ AGYCV 911_ ASYVL 916_ GIGDR 921_ HSDNI 926_ MVKKT 931_ GQLFH 936_ IDFGH 941_ ILGNF 946_ KSKFG 951_ IKRER 956_ VPFIL 961_ TYDFI 966_ HVIQQ 971_ GKTGN 976_ TEKFG 981_ RFRQC 986_ CEDAY 991_ LILRR 996_ HGNLF 1001_ ITLFA 1006_ LMLTA 1011_ GLPEL 1016_ TSVKD 1021_ IQYLK 1026_ DSLAL 1031_ GKSEE 1036_ EALKQ 1041_ FKQKF 1046_ DEALR 1051_ ESWTT 1056_ KVNWM 1061_AHTVR
1: Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Also has a protein kinase activity showing autophosphorylation (PubMed:12502714)