Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
1_MAAAA 6_ QLSLT 11_ QLSSG 16_ NPVYE 21_ KYYRQ 26_ VDTGN 31_ TGRVL 36_ ASDAA 41_ AFLKK 46_ SGLPD 51_ LILGK 56_ IWDLA 61_ DTDGK 66_ GILNK 71_ QEFFV 76_ ALRLV 81_ ACAQN 86_ GLEVS 91_ LSSLN 96_ LAVPP 101_ PRFHD 106_ TSSPL 111_ LISGT 116_ SAAEL 121_ PWAVK 126_ PEDKA 131_ KYDAI 136_ FDSLS 141_ PVNGF 146_ LSGDK 151_ VKPVL 156_ LNSKL 161_ PVDIL 166_ GRVWE 171_ LSDID 176_ HDGML 181_ DRDEF 186_ AVAMF 191_ LVYCA 196_ LEKEP 201_ VPMSL 206_ PPALV 211_ PPSKR 216_ KTWVV 221_ SPAEK 226_ AKYDE 231_ IFLKT 236_ DKDMD 241_ GFVSG 246_ LEVRE 251_ IFLKT 256_ GLPST 261_ LLAHI 266_ WSLCD 271_ TKDCG 276_ KLSKD 281_ QFALA 286_ FHLIS 291_ QKLIK 296_ GIDPP 301_ HVLTP 306_ EMIPP 311_ SDRAS 316_ LQKNI 321_ IGSSP 326_ VADFS 331_ AIKEL 336_ DTLNN 341_ EIVDL 346_ QREKN 351_ NVEQD 356_ LKEKE 361_ DTIKQ 366_ RTSEV 371_ QDLQD 376_ EVQRE 381_ NTNLQ 386_ KLQAQ 391_ KQQVQ 396_ ELLDE 401_ LDEQK 406_ AQLEE 411_ QLKEV 416_ RKKCA 421_ EEAQL 426_ ISSLK 431_ AELTS 436_ QESQI 441_ STYEE 446_ ELAKA 451_ REELS 456_ RLQQE 461_ TAELE 466_ ESVES 471_ GKAQL 476_ EPLQQ 481_ HLQDS 486_ QQEIS 491_ SMQMK 496_ LMEMK 501_ DLENH 506_ NSQLN 511_ WCSSP 516_ HSILV 521_ NGATD 526_ YCSLS 531_ TSSSE 536_ TANLN 541_ EHVEG 546_ QSNLE 551_ SEPIH 556_ QESPA 561_ RSSPE 566_ LLPSG 571_ VTDEN 576_ EVTTA 581_ VTEKV 586_ CSELD 591_ NNRHS 596_ KEEDP 601_ FNVDS 606_ SSLTG 611_ PVADT 616_ NLDFF 621_ QSDPF 626_ VGSDP 631_ FKDDP 636_ FGKID 641_ PFGGD 646_ PFKGS 651_ DPFAS 656_ DCFFR 661_ QSTDP 666_ FATSS 671_ TDPFS 676_ AANNS 681_ SITSV 686_ ETLKH 691_ NDPFA 696_ PGGTV 701_ VAASD 706_ SATDP 711_ FASVF 716_ GNESF 721_ GGGFA 726_ DFSTL 731_ SKVNN 736_ EDPFR 741_ SATSS 746_ SVSNV 751_ VITKN 756_ VFEET 761_ SVKSE 766_ DEPPA 771_ LPPKI 776_ GTPTR 781_ PCPLP 786_ PGKRS 791_ INKLD 796_ SPDPF 801_ KLNDP 806_ FQPFP 811_ GNDSP 816_ KEKDP 821_ EIFCD 826_ PFTSA 831_ TTTTN 836_ KEADP 841_ SNFAN 846_ FSAYP 851_ SEEDM 856_ IEWAK 861_ RESER 866_ EEEQR 871_ LARLN 876_ QQEQE 881_ DLELA 886_ IALSK 891_SEISE
1: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2