Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
1_MASSC 6_ AVQVK 11_ LELGH 16_ RAQVR 21_ KKPTV 26_ EGFTH 31_ DWMVF 36_ VRGPE 41_ HSNIQ 46_ HFVEK 51_ VVFHL 56_ HESFP 61_ RPKRV 66_ CKDPP 71_ YKVEE 76_ SGYAG 81_ FILPI 86_ EVYFK 91_ NKEEP 96_ RKVRF 101_ DYDLF 106_ LHLEG 111_ HPPVN 116_ HLRCE 121_ KLTFN 126_ NPTED 131_ FRRKL 136_ LKAGG 141_ DPNRS 146_ IHTSS 151_ SSSSS 156_ SSSSS 161_ SSSSS 166_ SSSSS 171_ SSSSS 176_ SSSSS 181_ SSSSS 186_ SSSSS 191_ TSFSK 196_ PHKLM 201_ KEHKE 206_ KPSKD 211_ SREHK 216_ SAFKE 221_ PSRDH 226_ NKSSK 231_ ESSKK 236_ PKENK 241_ PLKEE 246_ KIVPK 251_ MAFKE 256_ PKPMS 261_ KEPKP 266_ DSNLL 271_ TITSG 276_ QDKKA 281_ PSKRP 286_ PISDS 291_ EELSA 296_ KKRKK 301_ SSSEA 306_ LFKSF 311_ SSAPP 316_ LILTC 321_ SADKK 326_ QIKDK 331_ SHVKM 336_ GKVKI 341_ ESETS 346_ EKKKS 351_ TLPPF 356_ DDIVD 361_ PNDSD 366_ VEENI 371_ SSKSD 376_ SEQPS 381_ PASSS 386_ SSSSS 391_ SFTPS 396_ QTRQQ 401_ GPLRS 406_ IMKDL 411_ HSDDN 416_ EEESD 421_ EVEDN 426_ DNDSE 431_ MERPV 436_ NRGGS 441_ RSRRV 446_ SLSDG 451_ SDSES 456_ SSASS 461_ PLHHE 466_ PPPPL 471_ LKTNN 476_ NQILE 481_ VKSPI 486_ KQSKS 491_ DKQIK 496_ NGECD 501_ KAYLD 506_ ELVEL 511_ HRRLM 516_ TLRER 521_ HILQQ 526_ IVNLI 531_ EETGH 536_ FHITN 541_ TTFDF 546_ DLCSL 551_ DKTTV 556_ RKLQS 561_YLETS
1: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619, PubMed:30374167, PubMed:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114, PubMed:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me) (PubMed:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than conferring, HSC stemness (PubMed:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PubMed:31776511)