Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
1_MAAPS 6_ AGSWS 11_ TFQHK 16_ ELMAA 21_ DRGRR 26_ ILGVC 31_ GMHPH 36_ HQETL 41_ KKNRV 46_ VLAKQ 51_ LLLSE 56_ LLEHL 61_ LEKDI 66_ ITLEM 71_ RELIQ 76_ AKVGS 81_ FSQNV 86_ ELLNL 91_ LPKRG 96_ PQAFD 101_ AFCEA 106_ LRETK 111_ QGHLE 116_ DMLLT 121_ TLSGL 126_ QHVLP 131_ PLSCD 136_ YDLSL 141_ PFPVC 146_ ESCPL 151_ YKKLR 156_ LSTDT 161_ VEHSL 166_ DNKDG 171_ PVCLQ 176_ VKPCT 181_ PEFYQ 186_ THFQL 191_ AYRLQ 196_ SRPRG 201_ LALVL 206_ SNVHF 211_ TGEKE 216_ LEFRS 221_ GGDVD 226_ HSTLV 231_ TLFKL 236_ LGYDV 241_ HVLCD 246_ QTAQE 251_ MQEKL 256_ QNFAQ 261_ LPAHR 266_ VTDSC 271_ IVALL 276_ SHGVE 281_ GAIYG 286_ VDGKL 291_ LQLQE 296_ VFQLF 301_ DNANC 306_ PSLQN 311_ KPKMF 316_ FIQAC 321_ RGDET 326_ DRGVD 331_ QQDGK 336_ NHAGS 341_ PGCEE 346_ SDAGK 351_ EKLPK 356_ MRLPT 361_ RSDMI 366_ CGYAC 371_ LKGTA 376_ AMRNT 381_ KRGSW 386_ YIEAL 391_ AQVFS 396_ ERACD 401_ MHVAD 406_ MLVKV 411_ NALIK 416_ DREGY 421_ APGTE 426_ FHRCK 431_ EMSEY 436_ CSTLC 441_ RHLYL 446_FPGHP
1: Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321)
2: Acts as a positive regulator of apoptosis
3: Acts as a negative regulator of apoptosis
4: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death