Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)
1_MSNIC 6_ QRLWE 11_ YLEPY 16_ LPCLS 21_ TEADK 26_ STVIE 31_ NPGAL 36_ CSPQS 41_ QRHGH 46_ YFVAL 51_ FDYQA 56_ RTAED 61_ LSFRA 66_ GDKLQ 71_ VLDTL 76_ HEGWW 81_ FARHL 86_ EKRRD 91_ GSSQQ 96_ LQGYI 101_ PSNYV 106_ AEDRS 111_ LQAEP 116_ WFFGA 121_ IGRSD 126_ AEKQL 131_ LYSEN 136_ KTGSF 141_ LIRES 146_ ESQKG 151_ EFSLS 156_ VLDGA 161_ VVKHY 166_ RIKRL 171_ DEGGF 176_ FLTRR 181_ RIFST 186_ LNEFV 191_ SHYTK 196_ TSDGL 201_ CVKLG 206_ KPCLK 211_ IQVPA 216_ PFDLS 221_ YKTVD 226_ QWEID 231_ RNSIQ 236_ LLKRL 241_ GSGQF 246_ GEVWE 251_ GLWNN 256_ TTPVA 261_ VKTLK 266_ PGSMD 271_ PNDFL 276_ REAQI 281_ MKNLR 286_ HPKLI 291_ QLYAV 296_ CTLED 301_ PIYII 306_ TELMR 311_ HGSLQ 316_ EYLQN 321_ DTGSK 326_ IHLTQ 331_ QVDMA 336_ AQVAS 341_ GMAYL 346_ ESRNY 351_ IHRDL 356_ AARNV 361_ LVGEH 366_ NIYKV 371_ ADFGL 376_ ARVFK 381_ VDNED 386_ IYESR 391_ HEIKL 396_ PVKWT 401_ APEAI 406_ RSNKF 411_ SIKSD 416_ VWSFG 421_ ILLYE 426_ IITYG 431_ KMPYS 436_ GMTGA 441_ QVIQM 446_ LAQNY 451_ RLPQP 456_ SNCPQ 461_ QFYNI 466_ MLECW 471_ NAEPK 476_ ERPTF 481_ ETLRW 486_ KLEDY 491_ FETDS 496_SYSDA
1: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor