Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130)
1_MAALL 6_ RSARW 11_ LLRAG 16_ AAPRL 21_ PLSLR 26_ LLPGG 31_ PGRLH 36_ AASYL 41_ PAARA 46_ GPVAG 51_ GLLSP 56_ ARLYA 61_ IAAKE 66_ KDIQE 71_ ESTFS 76_ SRKIS 81_ NQFDW 86_ ALMRL 91_ DLSVR 96_ RTGRI 101_ PKKLL 106_ QKVFN 111_ DTCRS 116_ GGLGG 121_ SHALL 126_ LLRSC 131_ GSLLP 136_ ELKLE 141_ ERTEF 146_ AHRIW 151_ DTLQK 156_ LGAVY 161_ DVSHY 166_ NALLK 171_ VYLQN 176_ EYKFS 181_ PTDFL 186_ AKMEE 191_ ANIQP 196_ NRVTY 201_ QRLIA 206_ SYCNV 211_ GDIEG 216_ ASKIL 221_ GFMKT 226_ KDLPV 231_ TEAVF 236_ SALVT 241_ GHARA 246_ GDMEN 251_ AENIL 256_ TVMRD 261_ AGIEP 266_ GPDTY 271_ LALLN 276_ AYAEK 281_ GDIDH 286_ VKQTL 291_ EKVEK 296_ SELHL 301_ MDRDL 306_ LQIIF 311_ SFSKA 316_ GYPQY 321_ VSEIL 326_ EKVTC 331_ ERRYI 336_ PDAMN 341_ LILLL 346_ VTEKL 351_ EDVAL 356_ QILLA 361_ CPVSK 366_ EDGPS 371_ VFGSF 376_ FLQHC 381_ VTMNT 386_ PVEKL 391_ TDYCK 396_ KLKEV 401_ QMHSF 406_ PLQFT 411_ LHCAL 416_ LANKT 421_ DLAKA 426_ LMKAV 431_ KEEGF 436_ PIRPH 441_ YFWPL 446_ LVGRR 451_ KEKNV 456_ QGIIE 461_ ILKGM 466_ QELGV 471_ HPDQE 476_ TYTDY 481_ VIPCF 486_ DSVNS 491_ ARAIL 496_ QENGC 501_ LSDSD 506_ MFSQA 511_ GLRSE 516_ AANGN 521_ LDFVL 526_ SFLKS 531_ NTLPI 536_ SLQSI 541_ RSSLL 546_ LGFRR 551_ SMNIN 556_ LWSEI 561_ TELLY 566_ KDGRY 571_ CQEPR 576_ GPTEA 581_ VGYFL 586_ YNLID 591_ SMSDS 596_ EVQAK 601_ EEHLR 606_ QYFHQ 611_ LEKMN 616_ VKIPE 621_ NIYRG 626_ IRNLL 631_ ESYHV 636_ PELIK 641_ DAHLL 646_ VESKN 651_ LDFQK 656_ TVQLT 661_ SSELE 666_ STLET 671_ LKAEN 676_ QPIRD 681_ VLKQL 686_ ILVLC 691_ SEENM 696_ QKALE 701_ LKAKY 706_ ESDMV 711_ TGGYA 716_ ALINL 721_ CCRHD 726_ KVEDA 731_ LNLKE 736_ EFDRL 741_ DSSAV 746_ LDTGK 751_ YVGLV 756_ RVLAK 761_ HGKLQ 766_ DAINI 771_ LKEMK 776_ EKDVL 781_ IKDTT 786_ ALSFF 791_ HMLNG 796_ AALRG 801_ EIETV 806_ KQLHE 811_ AIVTL 816_ GLAEP 821_ STNIS 826_ FPLVT 831_ VHLEK 836_ GDLST 841_ ALEVA 846_ IDCYE 851_ KYKVL 856_ PRIHD 861_ VLCKL 866_ VEKGE 871_ TDLIQ 876_ KAMDF 881_ VSQEQ 886_ GEMVM 891_ LYDLF 896_ FAFLQ 901_ TGNYK 906_ EAKKI 911_ IETPG 916_ IRARS 921_ ARLQW 926_ FCDRC 931_ VANNQ 936_ VETLE 941_ KLVEL 946_ TQKLF 951_ ECDRD 956_ QMYYN 961_ LLKLY 966_ KINGD 971_ WQRAD 976_ AVWNK 981_ IQEEN 986_ VIPRE 991_ KTLRL 996_ LAEIL 1001_ REGNQ 1006_ EVPFD 1011_ VPELW 1016_ YEDEK 1021_ HSLNS 1026_ SSAST 1031_ TEPDF 1036_ QKDIL 1041_ IACRL 1046_ NQKKG 1051_ AYDIF 1056_ LNAKE 1061_ QNIVF 1066_ NAETY 1071_ SNLIK 1076_ LLMSE 1081_ DYFTQ 1086_ AMEVK 1091_ AFAET 1096_ HIKGF 1101_ TLNDA 1106_ ANSRL 1111_ IITQV 1116_ RRDYL 1121_ KEAVT 1126_ TLKTV 1131_ LDQQQ 1136_ TPSRL 1141_ AVTRV 1146_ IQALA 1151_ MKGDV 1156_ ENIEV 1161_ VQKML 1166_ NGLED 1171_ SIGLS 1176_ KMVFI 1181_ NNIAL 1186_ AQIKN 1191_ NNIDA 1196_ AIENI 1201_ ENMLT 1206_ SENKV 1211_ IEPQY 1216_ FGLAY 1221_ LFRKV 1226_ IEEQL 1231_ EPAVE 1236_ KISIM 1241_ AERLA 1246_ NQFAI 1251_ YKPVT 1256_ DFFLQ 1261_ LVDAG 1266_ KVDDA 1271_ RALLQ 1276_ RCGAI 1281_ AEQTP 1286_ ILLLF 1291_ LLRNS 1296_ RKQGK 1301_ ASTVK 1306_ SVLEL 1311_ IPELN 1316_ EKEEA 1321_ YNSLM 1326_ KSYVS 1331_ EKDVT 1336_ SAKAL 1341_ YEHLT 1346_ AKNTK 1351_ LDDLF 1356_ LKRYA 1361_ SLLKY 1366_ AGEPV 1371_ PFIEP 1376_ PESFE 1381_ FYAQQ 1386_LRKLR
1: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex (PubMed:19262567, PubMed:28325843). Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm (PubMed:28325843). May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). Required for maintaining mitochondrial potential (PubMed:23822101). Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels (PubMed:23822101)