3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-) (EC 3.1.2.1) (EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)
1_MALLR 6_ GVFVV 11_ AAKRT 16_ PFGAY 21_ GGLLK 26_ DFTAT 31_ DLSEF 36_ AAKAA 41_ LSAGK 46_ VSPET 51_ VDSVI 56_ MGNVL 61_ QSSSD 66_ AIYLA 71_ RHVGL 76_ RVGIP 81_ KETPA 86_ LTINR 91_ LCGSG 96_ FQSIV 101_ NGCQE 106_ ICVKE 111_ AEVVL 116_ CGGTE 121_ SMSQA 126_ PYCVR 131_ NVRFG 136_ TKLGS 141_ DIKLE 146_ DSLWV 151_ SLTDQ 156_ HVQLP 161_ MAMTA 166_ ENLAV 171_ KHKIS 176_ REECD 181_ KYALQ 186_ SQQRW 191_ KAAND 196_ AGYFN 201_ DEMAP 206_ IEVKT 211_ KKGKQ 216_ TMQVD 221_ EHARP 226_ QTTLE 231_ QLQKL 236_ PPVFK 241_ KDGTV 246_ TAGNA 251_ SGVAD 256_ GAGAV 261_ IIASE 266_ DAVKK 271_ HNFTP 276_ LARIV 281_ GYFVS 286_ GCDPS 291_ IMGIG 296_ PVPAI 301_ SGALK 306_ KAGLS 311_ LKDMD 316_ LVEVN 321_ EAFAP 326_ QYLAV 331_ ERSLD 336_ LDISK 341_ TNVNG 346_ GAIAL 351_ GHPLG 356_ GSGSR 361_ ITAHL 366_ VHELR 371_ RRGGK 376_ YAVGS 381_ ACIGG 386_ GQGIA 391_VIIQS
1: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312)