Wiskott-Aldrich syndrome protein (WASp)
1_MSGGP 6_ MGGRP 11_ GGRGA 16_ PAVQQ 21_ NIPST 26_ LLQDH 31_ ENQRL 36_ FEMLG 41_ RKCLT 46_ LATAV 51_ VQLYL 56_ ALPPG 61_ AEHWT 66_ KEHCG 71_ AVCFV 76_ KDNPQ 81_ KSYFI 86_ RLYGL 91_ QAGRL 96_ LWEQE 101_ LYSQL 106_ VYSTP 111_ TPFFH 116_ TFAGD 121_ DCQAG 126_ LNFAD 131_ EDEAQ 136_ AFRAL 141_ VQEKI 146_ QKRNQ 151_ RQSGD 156_ RRQLP 161_ PPPTP 166_ ANEER 171_ RGGLP 176_ PLPLH 181_ PGGDQ 186_ GGPPV 191_ GPLSL 196_ GLATV 201_ DIQNP 206_ DITSS 211_ RYRGL 216_ PAPGP 221_ SPADK 226_ KRSGK 231_ KKISK 236_ ADIGA 241_ PSGFK 246_ HVSHV 251_ GWDPQ 256_ NGFDV 261_ NNLDP 266_ DLRSL 271_ FSRAG 276_ ISEAQ 281_ LTDAE 286_ TSKLI 291_ YDFIE 296_ DQGGL 301_ EAVRQ 306_ EMRRQ 311_ EPLPP 316_ PPPPS 321_ RGGNQ 326_ LPRPP 331_ IVGGN 336_ KGRSG 341_ PLPPV 346_ PLGIA 351_ PPPPT 356_ PRGPP 361_ PPGRG 366_ GPPPP 371_ PPPAT 376_ GRSGP 381_ LPPPP 386_ PGAGG 391_ PPMPP 396_ PPPPP 401_ PPPPS 406_ SGNGP 411_ APPPL 416_ PPALV 421_ PAGGL 426_ APGGG 431_ RGALL 436_ DQIRQ 441_ GIQLN 446_ KTPGA 451_ PESSA 456_ LQPPP 461_ QSSEG 466_ LVGAL 471_ MHVMQ 476_ KRSRA 481_ IHSSD 486_ EGEDQ 491_ AGDED 496_EDDEW
1: Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905). Important for efficient actin polymerization (PubMed:12235133, PubMed:16275905, PubMed:8625410). Possible regulator of lymphocyte and platelet function (PubMed:9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)