Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
1_MEPAA 6_ GSSME 11_ PSADW 16_ LATAA 21_ ARGRV 26_ EEVRA 31_ LLEAG 36_ ALPNA 41_ PNSYG 46_ RRPIQ 51_ VMMMG 56_ SARVA 61_ ELLLL 66_ HGAEP 71_ NCADP 76_ ATLTR 81_ PVHDA 86_ AREGF 91_ LDTLV 96_ VLHRA 101_ GARLD 106_ VRDAW 111_ GRLPV 116_ DLAEE 121_ LGHRD 126_ VARYL 131_ RAAAG 136_ GTRGS 141_ NHARI 146_ DAAEG 151_PSDIP
1: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein