Neuronal vesicle trafficking-associated protein 1 (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1)
1_MVKLG 6_ NNFAE 11_ KGTKQ 16_ PLLED 21_ GFDTI 26_ PLMTP 31_ LDVNQ 36_ LQFPP 41_ PDKVV 46_ VKTKT 51_ EYEPD 56_ RKKGK 61_ ARPPQ 66_ IAEFT 71_ VSITE 76_ GVTER 81_ FKVSV 86_ LVLFA 91_ LAFLT 96_ CVVFL 101_ VVYKV 106_ YKYDR 111_ ACPDG 116_ FVLKN 121_ TQCIP 126_ EGLES 131_ YYAEQ 136_ DSSAR 141_ EKFYT 146_ VINHY 151_ NLAKQ 156_ SITRS 161_ VSPWM 166_ SVLSE 171_ EKLSE 176_QETEA
1: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061)