Methylenetetrahydrofolate reductase (EC 1.5.1.20)
1_MVNEA 6_ RGNSS 11_ LNPCL 16_ EGSAS 21_ SGSES 26_ SKDSS 31_ RCSTP 36_ GLDPE 41_ RHERL 46_ REKMR 51_ RRLES 56_ GDKWF 61_ SLEFF 66_ PPRTA 71_ EGAVN 76_ LISRF 81_ DRMAA 86_ GGPLY 91_ IDVTW 96_ HPAGD 101_ PGSDK 106_ ETSSM 111_ MIAST 116_ AVNYC 121_ GLETI 126_ LHMTC 131_ CRQRL 136_ EEITG 141_ HLHKA 146_ KQLGL 151_ KNIMA 156_ LRGDP 161_ IGDQW 166_ EEEEG 171_ GFNYA 176_ VDLVK 181_ HIRSE 186_ FGDYF 191_ DICVA 196_ GYPKG 201_ HPEAG 206_ SFEAD 211_ LKHLK 216_ EKVSA 221_ GADFI 226_ ITQLF 231_ FEADT 236_ FFRFV 241_ KACTD 246_ MGITC 251_ PIVPG 256_ IFPIQ 261_ GYHSL 266_ RQLVK 271_ LSKLE 276_ VPQEI 281_ KDVIE 286_ PIKDN 291_ DAAIR 296_ NYGIE 301_ LAVSL 306_ CQELL 311_ ASGLV 316_ PGLHF 321_ YTLNR 326_ EMATT 331_ EVLKR 336_ LGMWT 341_ EDPRR 346_ PLPWA 351_ LSAHP 356_ KRREE 361_ DVRPI 366_ FWASR 371_ PKSYI 376_ YRTQE 381_ WDEFP 386_ NGRWG 391_ NSSSP 396_ AFGEL 401_ KDYYL 406_ FYLKS 411_ KSPKE 416_ ELLKM 421_ WGEEL 426_ TSEES 431_ VFEVF 436_ VLYLS 441_ GEPNR 446_ NGHKV 451_ TCLPW 456_ NDEPL 461_ AAETS 466_ LLKEE 471_ LLRVN 476_ RQGIL 481_ TINSQ 486_ PNING 491_ KPSSD 496_ PIVGW 501_ GPSGG 506_ YVFQK 511_ AYLEF 516_ FTSRE 521_ TAEAL 526_ LQVLK 531_ KYELR 536_ VNYHL 541_ VNVKG 546_ ENITN 551_ APELQ 556_ PNAVT 561_ WGIFP 566_ GREII 571_ QPTVV 576_ DPVSF 581_ MFWKD 586_ EAFAL 591_ WIERW 596_ GKLYE 601_ EESPS 606_ RTIIQ 611_ YIHDN 616_ YFLVN 621_ LVDND 626_ FPLDN 631_ CLWQV 636_ VEDTL 641_ ELLNR 646_ PTQNA 651_RETEA
1: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable)