Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
1_MGKPA 6_ RKGCE 11_ WKRFL 16_ KNNWV 21_ LLSTV 26_ AAVVL 31_ GITTG 36_ VLVRE 41_ HSNLS 46_ TLEKF 51_ YFAFP 56_ GEILM 61_ RMLKL 66_ IILPL 71_ IISSM 76_ ITGVA 81_ ALDSN 86_ VSGKI 91_ GLRAV 96_ VYYFC 101_ TTLIA 106_ VILGI 111_ VLVVS 116_ IKPGV 121_ TQKVG 126_ EIART 131_ GSTPE 136_ VSTVD 141_ AMLDL 146_ IRNMF 151_ PENLV 156_ QACFQ 161_ QYKTK 166_ REEVK 171_ PPSDP 176_ EMNMT 181_ EESFT 186_ AVMTT 191_ AISKN 196_ KTKEY 201_ KIVGM 206_ YSDGI 211_ NVLGL 216_ IVFCL 221_ VFGLV 226_ IGKMG 231_ EKGQI 236_ LVDFF 241_ NALSD 246_ ATMKI 251_ VQIIM 256_ CYMPL 261_ GILFL 266_ IAGKI 271_ IEVED 276_ WEIFR 281_ KLGLY 286_ MATVL 291_ TGLAI 296_ HSIVI 301_ LPLIY 306_ FIVVR 311_ KNPFR 316_ FAMGM 321_ AQALL 326_ TALMI 331_ SSSSA 336_ TLPVT 341_ FRCAE 346_ ENNQV 351_ DKRIT 356_ RFVLP 361_ VGATI 366_ NMDGT 371_ ALYEA 376_ VAAVF 381_ IAQLN 386_ DLDLG 391_ IGQII 396_ TISIT 401_ ATSAS 406_ IGAAG 411_ VPQAG 416_ LVTMV 421_ IVLSA 426_ VGLPA 431_ EDVTL 436_ IIAVD 441_ WLLDR 446_ FRTMV 451_ NVLGD 456_ AFGTG 461_ IVEKL 466_ SKKEL 471_ EQMDV 476_ SSEVN 481_ IVNPF 486_ ALEST 491_ ILDNE 496_ DSDTK 501_ KSYVN 506_ GGFAV 511_ DKSDT 516_ISFTQ
1: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:21123949, PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:7914198, PubMed:8857541). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:26690923, PubMed:33658209, PubMed:7521911, PubMed:8857541). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:26690923, PubMed:8857541). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity)