Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
1_MRLPK 6_ LLTFL 11_ LWYLA 16_ WLDLE 21_ FICTV 26_ LGAPD 31_ LGQRP 36_ QGTRP 41_ GLAKA 46_ EAKER 51_ PPLAR 56_ NVFRP 61_ GGHSY 66_ GGGAT 71_ NANAR 76_ AKGGT 81_ GQTGG 86_ LTQPK 91_ KDEPK 96_ KLPPR 101_ PGGPE 106_ PKPGH 111_ PPQTR 116_ QATAR 121_ TVTPK 126_ GQLPG 131_ GKAPP 136_ KAGSV 141_ PSSFL 146_ LKKAR 151_ EPGPP 156_ REPKE 161_ PFRPP 166_ PITPH 171_ EYMLS 176_ LYRTL 181_ SDADR 186_ KGGNS 191_ SVKLE 196_ AGLAN 201_ TITSF 206_ IDKGQ 211_ DDRGP 216_ VVRKQ 221_ RYVFD 226_ ISALE 231_ KDGLL 236_ GAELR 241_ ILRKK 246_ PSDTA 251_ KPAAP 256_ GGGRA 261_ AQLKL 266_ SSCPS 271_ GRQPA 276_ ALLDV 281_ RSVPG 286_ LDGSG 291_ WEVFD 296_ IWKLF 301_ RNFKN 306_ SAQLC 311_ LELEA 316_ WERGR 321_ AVDLR 326_ GLGFD 331_ RAARQ 336_ VHEKA 341_ LFLVF 346_ GRTKK 351_ RDLFF 356_ NEIKA 361_ RSGQD 366_ DKTVY 371_ EYLFS 376_ QRRKR 381_ RAPLA 386_ TRQGK 391_ RPSKN 396_ LKARC 401_ SRKAL 406_ HVNFK 411_ DMGWD 416_ DWIIA 421_ PLEYE 426_ AFHCE 431_ GLCEF 436_ PLRSH 441_ LEPTN 446_ HAVIQ 451_ TLMNS 456_ MDPES 461_ TPPTC 466_ CVPTR 471_ LSPIS 476_ ILFID 481_ SANNV 486_ VYKQY 491_ EDMVV 496_ESCGC
1: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:15530414, PubMed:21976273, PubMed:24098149, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205)