Platelet-activating factor acetylhydrolase IB subunit beta (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)
1_MVLSQ 6_ RQRDE 11_ LNRAI 16_ ADYLR 21_ SNGYE 26_ EAYSV 31_ FKKEA 36_ ELDVN 41_ EELDK 46_ KYAGL 51_ LEKKW 56_ TSVIR 61_ LQKKV 66_ MELES 71_ KLNEA 76_ KEEFT 81_ SGGPL 86_ GQKRD 91_ PKEWI 96_ PRPPE 101_ KYALS 106_ GHRSP 111_ VTRVI 116_ FHPVF 121_ SVMVS 126_ ASEDA 131_ TIKVW 136_ DYETG 141_ DFERT 146_ LKGHT 151_ DSVQD 156_ ISFDH 161_ SGKLL 166_ ASCSA 171_ DMTIK 176_ LWDFQ 181_ GFECI 186_ RTMHG 191_ HDHNV 196_ SSVAI 201_ MPNGD 206_ HIVSA 211_ SRDKT 216_ IKMWE 221_ VQTGY 226_ CVKTF 231_ TGHRE 236_ WVRMV 241_ RPNQD 246_ GTLIA 251_ SCSND 256_ QTVRV 261_ WVVAT 266_ KECKA 271_ ELREH 276_ EHVVE 281_ CISWA 286_ PESSY 291_ SSISE 296_ ATGSE 301_ TKKSG 306_ KPGPF 311_ LLSGS 316_ RDKTI 321_ KMWDV 326_ STGMC 331_ LMTLV 336_ GHDNW 341_ VRGVL 346_ FHSGG 351_ KFILS 356_ CADDK 361_ TLRVW 366_ DYKNK 371_ RCMKT 376_ LNAHE 381_ HFVTS 386_ LDFHK 391_ TAPYV 396_ VTGSV 401_DQTVK
1: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)