Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A)
1_MGNVM 6_ EGKSV 11_ EELSS 16_ TECHQ 21_ WYKKF 26_ MTECP 31_ SGQLT 36_ LYEFR 41_ QFFGL 46_ KNLSP 51_ SASQY 56_ VEQMF 61_ ETFDF 66_ NKDGY 71_ IDFME 76_ YVAAL 81_ SLVLK 86_ GKVEQ 91_ KLRWY 96_ FKLYD 101_ VDGNG 106_ CIDRD 111_ ELLTI 116_ IQAIR 121_ AINPC 126_ SDTTM 131_ TAEEF 136_ TDTVF 141_ SKIDV 146_ NGDGE 151_ LSLEE 156_ FIEGV 161_ QKDQM 166_ LLDTL 171_ TRSLD 176_ LTRIV 181_ RRLQN 186_ GEQDE 191_ EGADE 196_AAEAA
1: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:18706439, PubMed:19459154, PubMed:30184081, PubMed:30622141). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity)