Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
1_MKETR 6_ GYGGD 11_ APFCT 16_ RLNHS 21_ YTGMW 26_ APERS 31_ AEARG 36_ NLTRP 41_ PGSGE 46_ DCGSV 51_ SVAFP 56_ ITMLL 61_ TGFVG 66_ NALAM 71_ LLVSR 76_ SYRRR 81_ ESKRK 86_ KSFLL 91_ CIGWL 96_ ALTDL 101_ VGQLL 106_ TTPVV 111_ IVVYL 116_ SKQRW 121_ EHIDP 126_ SGRLC 131_ TFFGL 136_ TMTVF 141_ GLSSL 146_ FIASA 151_ MAVER 156_ ALAIR 161_ APHWY 166_ ASHMK 171_ TRATR 176_ AVLLG 181_ VWLAV 186_ LAFAL 191_ LPVLG 196_ VGQYT 201_ VQWPG 206_ TWCFI 211_ STGRG 216_ GNGTS 221_ SSHNW 226_ GNLFF 231_ ASAFA 236_ FLGLL 241_ ALTVT 246_ FSCNL 251_ ATIKA 256_ LVSRC 261_ RAKAT 266_ ASQSS 271_ AQWGR 276_ ITTET 281_ AIQLM 286_ GIMCV 291_ LSVCW 296_ SPLLI 301_ MMLKM 306_ IFNQT 311_ SVEHC 316_ KTHTE 321_ KQKEC 326_ NFFLI 331_ AVRLA 336_ SLNQI 341_ LDPWV 346_ YLLLR 351_ KILLR 356_ KFCQI 361_ RYHTN 366_ NYASS 371_ STSLP 376_ CQCSS 381_TLMWS
1: Receptor for prostaglandin E2 (PGE2) (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729, PubMed:8307176). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity)