Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
1_MGLPR 6_ LVCAF 11_ LLAAC 16_ CCCPR 21_ VAGVP 26_ GEAEQ 31_ PAPEL 36_ VEVEV 41_ GSTAL 46_ LKCGL 51_ SQSQG 56_ NLSHV 61_ DWFSV 66_ HKEKR 71_ TLIFR 76_ VRQGQ 81_ GQSEP 86_ GEYEQ 91_ RLSLQ 96_ DRGAT 101_ LALTQ 106_ VTPQD 111_ ERIFL 116_ CQGKR 121_ PRSQE 126_ YRIQL 131_ RVYKA 136_ PEEPN 141_ IQVNP 146_ LGIPV 151_ NSKEP 156_ EEVAT 161_ CVGRN 166_ GYPIP 171_ QVIWY 176_ KNGRP 181_ LKEEK 186_ NRVHI 191_ QSSQT 196_ VESSG 201_ LYTLQ 206_ SILKA 211_ QLVKE 216_ DKDAQ 221_ FYCEL 226_ NYRLP 231_ SGNHM 236_ KESRE 241_ VTVPV 246_ FYPTE 251_ KVWLE 256_ VEPVG 261_ MLKEG 266_ DRVEI 271_ RCLAD 276_ GNPPP 281_ HFSIS 286_ KQNPS 291_ TREAE 296_ EETTN 301_ DNGVL 306_ VLEPA 311_ RKEHS 316_ GRYEC 321_ QGLDL 326_ DTMIS 331_ LLSEP 336_ QELLV 341_ NYVSD 346_ VRVSP 351_ AAPER 356_ QEGSS 361_ LTLTC 366_ EAESS 371_ QDLEF 376_ QWLRE 381_ ETGQV 386_ LERGP 391_ VLQLH 396_ DLKRE 401_ AGGGY 406_ RCVAS 411_ VPSIP 416_ GLNRT 421_ QLVNV 426_ AIFGP 431_ PWMAF 436_ KERKV 441_ WVKEN 446_ MVLNL 451_ SCEAS 456_ GHPRP 461_ TISWN 466_ VNGTA 471_ SEQDQ 476_ DPQRV 481_ LSTLN 486_ VLVTP 491_ ELLET 496_ GVECT 501_ ASNDL 506_ GKNTS 511_ ILFLE 516_ LVNLT 521_ TLTPD 526_ SNTTT 531_ GLSTS 536_ TASPH 541_ TRANS 546_ TSTER 551_ KLPEP 556_ ESRGV 561_ VIVAV 566_ IVCIL 571_ VLAVL 576_ GAVLY 581_ FLYKK 586_ GKLPC 591_ RRSGK 596_ QEITL 601_ PPSRK 606_ SELVV 611_ EVKSD 616_ KLPEE 621_ MGLLQ 626_ GSSGD 631_ KRAPG 636_ DQGEK 641_YIDLR
1: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration