Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X)
1_MWGLK 6_ VLLLP 11_ VVSFA 16_ LYPEE 21_ ILDTH 26_ WELWK 31_ KTHRK 36_ QYNNK 41_ VDEIS 46_ RRLIW 51_ EKNLK 56_ YISIH 61_ NLEAS 66_ LGVHT 71_ YELAM 76_ NHLGD 81_ MTSEE 86_ VVQKM 91_ TGLKV 96_ PLSHS 101_ RSNDT 106_ LYIPE 111_ WEGRA 116_ PDSVD 121_ YRKKG 126_ YVTPV 131_ KNQGQ 136_ CGSCW 141_ AFSSV 146_ GALEG 151_ QLKKK 156_ TGKLL 161_ NLSPQ 166_ NLVDC 171_ VSEND 176_ GCGGG 181_ YMTNA 186_ FQYVQ 191_ KNRGI 196_ DSEDA 201_ YPYVG 206_ QEESC 211_ MYNPT 216_ GKAAK 221_ CRGYR 226_ EIPEG 231_ NEKAL 236_ KRAVA 241_ RVGPV 246_ SVAID 251_ ASLTS 256_ FQFYS 261_ KGVYY 266_ DESCN 271_ SDNLN 276_ HAVLA 281_ VGYGI 286_ QKGNK 291_ HWIIK 296_ NSWGE 301_ NWGNK 306_ GYILM 311_ ARNKN 316_ NACGI 321_ANLAS
1: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042)