DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)
1_MAVQP 6_ KETLQ 11_ LESAA 16_ EVGFV 21_ RFFQG 26_ MPEKP 31_ TTTVR 36_ LFDRG 41_ DFYTA 46_ HGEDA 51_ LLAAR 56_ EVFKT 61_ QGVIK 66_ YMGPA 71_ GAKNL 76_ QSVVL 81_ SKMNF 86_ ESFVK 91_ DLLLV 96_ RQYRV 101_ EVYKN 106_ RAGNK 111_ ASKEN 116_ DWYLA 121_ YKASP 126_ GNLSQ 131_ FEDIL 136_ FGNND 141_ MSASI 146_ GVVGV 151_ KMSAV 156_ DGQRQ 161_ VGVGY 166_ VDSIQ 171_ RKLGL 176_ CEFPD 181_ NDQFS 186_ NLEAL 191_ LIQIG 196_ PKECV 201_ LPGGE 206_ TAGDM 211_ GKLRQ 216_ IIQRG 221_ GILIT 226_ ERKKA 231_ DFSTK 236_ DIYQD 241_ LNRLL 246_ KGKKG 251_ EQMNS 256_ AVLPE 261_ MENQV 266_ AVSSL 271_ SAVIK 276_ FLELL 281_ SDDSN 286_ FGQFE 291_ LTTFD 296_ FSQYM 301_ KLDIA 306_ AVRAL 311_ NLFQG 316_ SVEDT 321_ TGSQS 326_ LAALL 331_ NKCKT 336_ PQGQR 341_ LVNQW 346_ IKQPL 351_ MDKNR 356_ IEERL 361_ NLVEA 366_ FVEDA 371_ ELRQT 376_ LQEDL 381_ LRRFP 386_ DLNRL 391_ AKKFQ 396_ RQAAN 401_ LQDCY 406_ RLYQG 411_ INQLP 416_ NVIQA 421_ LEKHE 426_ GKHQK 431_ LLLAV 436_ FVTPL 441_ TDLRS 446_ DFSKF 451_ QEMIE 456_ TTLDM 461_ DQVEN 466_ HEFLV 471_ KPSFD 476_ PNLSE 481_ LREIM 486_ NDLEK 491_ KMQST 496_ LISAA 501_ RDLGL 506_ DPGKQ 511_ IKLDS 516_ SAQFG 521_ YYFRV 526_ TCKEE 531_ KVLRN 536_ NKNFS 541_ TVDIQ 546_ KNGVK 551_ FTNSK 556_ LTSLN 561_ EEYTK 566_ NKTEY 571_ EEAQD 576_ AIVKE 581_ IVNIS 586_ SGYVE 591_ PMQTL 596_ NDVLA 601_ QLDAV 606_ VSFAH 611_ VSNGA 616_ PVPYV 621_ RPAIL 626_ EKGQG 631_ RIILK 636_ ASRHA 641_ CVEVQ 646_ DEIAF 651_ IPNDV 656_ YFEKD 661_ KQMFH 666_ IITGP 671_ NMGGK 676_ STYIR 681_ QTGVI 686_ VLMAQ 691_ IGCFV 696_ PCESA 701_ EVSIV 706_ DCILA 711_ RVGAG 716_ DSQLK 721_ GVSTF 726_ MAEML 731_ ETASI 736_ LRSAT 741_ KDSLI 746_ IIDEL 751_ GRGTS 756_ TYDGF 761_ GLAWA 766_ ISEYI 771_ ATKIG 776_ AFCMF 781_ ATHFH 786_ ELTAL 791_ ANQIP 796_ TVNNL 801_ HVTAL 806_ TTEET 811_ LTMLY 816_ QVKKG 821_ VCDQS 826_ FGIHV 831_ AELAN 836_ FPKHV 841_ IECAK 846_ QKALE 851_ LEEFQ 856_ YIGES 861_ QGYDI 866_ MEPAA 871_ KKCYL 876_ EREQG 881_ EKIIQ 886_ EFLSK 891_ VKQMP 896_ FTEMS 901_ EENIT 906_ IKLKQ 911_ LKAEV 916_ IAKNN 921_ SFVNE 926_IISRI
1: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis