G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
1_MELEN 6_ IVANT 11_ VLLKA 16_ REGGG 21_ GNRKG 26_ KSKKW 31_ RQMLQ 36_ FPHIS 41_ QCEEL 46_ RLSLE 51_ RDYHS 56_ LCERQ 61_ PIGRL 66_ LFREF 71_ CATRP 76_ ELSRC 81_ VAFLD 86_ GVAEY 91_ EVTPD 96_ DKRKA 101_ CGRQL 106_ TQNFL 111_ SHTGP 116_ DLIPE 121_ VPRQL 126_ VTNCT 131_ QRLEQ 136_ GPCKD 141_ LFQEL 146_ TRLTH 151_ EYLSV 156_ APFAD 161_ YLDSI 166_ YFNRF 171_ LQWKW 176_ LERQP 181_ VTKNT 186_ FRQYR 191_ VLGKG 196_ GFGEV 201_ CACQV 206_ RATGK 211_ MYACK 216_ KLEKK 221_ RIKKR 226_ KGEAM 231_ ALNEK 236_ QILEK 241_ VNSRF 246_ VVSLA 251_ YAYET 256_ KDALC 261_ LVLTL 266_ MNGGD 271_ LKFHI 276_ YHMGQ 281_ AGFPE 286_ ARAVF 291_ YAAEI 296_ CCGLE 301_ DLHRE 306_ RIVYR 311_ DLKPE 316_ NILLD 321_ DHGHI 326_ RISDL 331_ GLAVH 336_ VPEGQ 341_ TIKGR 346_ VGTVG 351_ YMAPE 356_ VVKNE 361_ RYTFS 366_ PDWWA 371_ LGCLL 376_ YEMIA 381_ GQSPF 386_ QQRKK 391_ KIKRE 396_ EVERL 401_ VKEVP 406_ EEYSE 411_ RFSPQ 416_ ARSLC 421_ SQLLC 426_ KDPAE 431_ RLGCR 436_ GGSAR 441_ EVKEH 446_ PLFKK 451_ LNFKR 456_ LGAGM 461_ LEPPF 466_ KPDPQ 471_ AIYCK 476_ DVLDI 481_ EQFST 486_ VKGVE 491_ LEPTD 496_ QDFYQ 501_ KFATG 506_ SVPIP 511_ WQNEM 516_ VETEC 521_ FQELN 526_ VFGLD 531_ GSVPP 536_ DLDWK 541_ GQPPA 546_ PPKKG 551_ LLQRL 556_ FSRQD 561_ CCGNC 566_ SDSEE 571_ELPTR
1: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro)