Gene name: MAGEA1

Uniprot entry:

P43355

Protein names:

Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)

Protein sequence:

1_MSLEQ 6_ RSLHC 11_ KPEEA 16_ LEAQQ 21_ EALGL 26_ VCVQA 31_ ATSSS 36_ SPLVL 41_ GTLEE 46_ VPTAG 51_ STDPP 56_ QSPQG 61_ ASAFP 66_ TTINF 71_ TRQRQ 76_ PSEGS 81_ SSREE 86_ EGPST 91_ SCILE 96_ SLFRA 101_ VITKK 106_ VADLV 111_ GFLLL 116_ KYRAR 121_ EPVTK 126_ AEMLE 131_ SVIKN 136_ YKHCF 141_ PEIFG 146_ KASES 151_ LQLVF 156_ GIDVK 161_ EADPT 166_ GHSYV 171_ LVTCL 176_ GLSYD 181_ GLLGD 186_ NQIMP 191_ KTGFL 196_ IIVLV 201_ MIAME 206_ GGHAP 211_ EEEIW 216_ EELSV 221_ MEVYD 226_ GREHS 231_ AYGEP 236_ RKLLT 241_ QDLVQ 246_ EKYLE 251_ YRQVP 256_ DSDPA 261_ RYEFL 266_ WGPRA 271_ LAETS 276_ YVKVL 281_ EYVIK 286_ VSARV 291_ RFFFP 296_ SLREA 301_ALREE

Protein annotations

Protein functions:

1: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes