Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)
1_MPLEQ 6_ RSQHC 11_ KPEEG 16_ LEARG 21_ EALGL 26_ VGAQA 31_ PATEE 36_ QEAAS 41_ SSSTL 46_ VEVTL 51_ GEVPA 56_ AESPD 61_ PPQSP 66_ QGASS 71_ LPTTM 76_ NYPLW 81_ SQSYE 86_ DSSNQ 91_ EEEGP 96_ STFPD 101_ LESEF 106_ QAALS 111_ RKVAE 116_ LVHFL 121_ LLKYR 126_ AREPV 131_ TKAEM 136_ LGSVV 141_ GNWQY 146_ FFPVI 151_ FSKAS 156_ SSLQL 161_ VFGIE 166_ LMEVD 171_ PIGHL 176_ YIFAT 181_ CLGLS 186_ YDGLL 191_ GDNQI 196_ MPKAG 201_ LLIIV 206_ LAIIA 211_ REGDC 216_ APEEK 221_ IWEEL 226_ SVLEV 231_ FEGRE 236_ DSILG 241_ DPKKL 246_ LTQHF 251_ VQENY 256_ LEYRQ 261_ VPGSD 266_ PACYE 271_ FLWGP 276_ RALVE 281_ TSYVK 286_ VLHHM 291_ VKISG 296_ GPHIS 301_ YPPLH 306_EWVLR
1: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684)