Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)
1_MAAAK 6_ DTHED 11_ HDTST 16_ ENTDE 21_ SNHDP 26_ QFEPI 31_ VSLPE 36_ QEIKT 41_ LEEDE 46_ EELFK 51_ MRAKL 56_ FRFAS 61_ ENDLP 66_ EWKER 71_ GTGDV 76_ KLLKH 81_ KEKGA 86_ IRLLM 91_ RRDKT 96_ LKICA 101_ NHYIT 106_ PMMEL 111_ KPNAG 116_ SDRAW 121_ VWNTH 126_ ADFAD 131_ ECPKP 136_ ELLAI 141_ RFLNA 146_ ENAQK 151_ FKTKF 156_ EECRK 161_ EIEER 166_ EKKAG 171_ SGKND 176_ HAEKV 181_ AEKLE 186_ ALSVK 191_ EETKE 196_DAEEK
1: Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974)