Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)
1_MNPAA 6_ EAEFN 11_ ILLAT 16_ DSYKV 21_ THYKQ 26_ YPPNT 31_ SKVYS 36_ YFECR 41_ EKKTE 46_ NSKLR 51_ KVKYE 56_ ETVFY 61_ GLQYI 66_ LNKYL 71_ KGKVV 76_ TKEKI 81_ QEAKD 86_ VYKEH 91_ FQDDV 96_ FNEKG 101_ WNYIL 106_ EKYDG 111_ HLPIE 116_ IKAVP 121_ EGFVI 126_ PRGNV 131_ LFTVE 136_ NTDPE 141_ CYWLT 146_ NWIET 151_ ILVQS 156_ WYPIT 161_ VATNS 166_ REQKK 171_ ILAKY 176_ LLETS 181_ GNLDG 186_ LEYKL 191_ HDFGY 196_ RGVSS 201_ QETAG 206_ IGASA 211_ HLVNF 216_ KGTDT 221_ VAGLA 226_ LIKKY 231_ YGTKD 236_ PVPGY 241_ SVPAA 246_ EHSTI 251_ TAWGK 256_ DHEKD 261_ AFEHI 266_ VTQFS 271_ SVPVS 276_ VVSDS 281_ YDIYN 286_ ACEKI 291_ WGEDL 296_ RHLIV 301_ SRSTQ 306_ APLII 311_ RPDSG 316_ NPLDT 321_ VLKVL 326_ EILGK 331_ KFPVT 336_ ENSKG 341_ YKLLP 346_ PYLRV 351_ IQGDG 356_ VDINT 361_ LQEIV 366_ EGMKQ 371_ KMWSI 376_ ENIAF 381_ GSGGG 386_ LLQKL 391_ TRDLL 396_ NCSFK 401_ CSYVV 406_ TNGLG 411_ INVFK 416_ DPVAD 421_ PNKRS 426_ KKGRL 431_ SLHRT 436_ PAGNF 441_ VTLEE 446_ GKGDL 451_ EEYGQ 456_ DLLHT 461_ VFKNG 466_ KVTKS 471_ YSFDE 476_ IRKNA 481_ QLNIE 486_LEAAH
1: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity)