Neuronal acetylcholine receptor subunit alpha-4
1_MELGG 6_ PGAPR 11_ LLPPL 16_ LLLLG 21_ TGLLR 26_ ASSHV 31_ ETRAH 36_ AEERL 41_ LKKLF 46_ SGYNK 51_ WSRPV 56_ ANISD 61_ VVLVR 66_ FGLSI 71_ AQLID 76_ VDEKN 81_ QMMTT 86_ NVWVK 91_ QEWHD 96_ YKLRW 101_ DPADY 106_ ENVTS 111_ IRIPS 116_ ELIWR 121_ PDIVL 126_ YNNAD 131_ GDFAV 136_ THLTK 141_ AHLFH 146_ DGRVQ 151_ WTPPA 156_ IYKSS 161_ CSIDV 166_ TFFPF 171_ DQQNC 176_ TMKFG 181_ SWTYD 186_ KAKID 191_ LVNMH 196_ SRVDQ 201_ LDFWE 206_ SGEWV 211_ IVDAV 216_ GTYNT 221_ RKYEC 226_ CAEIY 231_ PDITY 236_ AFVIR 241_ RLPLF 246_ YTINL 251_ IIPCL 256_ LISCL 261_ TVLVF 266_ YLPSE 271_ CGEKI 276_ TLCIS 281_ VLLSL 286_ TVFLL 291_ LITEI 296_ IPSTS 301_ LVIPL 306_ IGEYL 311_ LFTMI 316_ FVTLS 321_ IVITV 326_ FVLNV 331_ HHRSP 336_ RTHTM 341_ PTWVR 346_ RVFLD 351_ IVPRL 356_ LLMKR 361_ PSVVK 366_ DNCRR 371_ LIESM 376_ HKMAS 381_ APRFW 386_ PEPEG 391_ EPPAT 396_ SGTQS 401_ LHPPS 406_ PSFCV 411_ PLDVP 416_ AEPGP 421_ SCKSP 426_ SDQLP 431_ PQQPL 436_ EAEKA 441_ SPHPS 446_ PGPCR 451_ PPHGT 456_ QAPGL 461_ AKARS 466_ LSVQH 471_ MSSPG 476_ EAVEG 481_ GVRCR 486_ SRSIQ 491_ YCVPR 496_ DDAAP 501_ EADGQ 506_ AAGAL 511_ ASRNT 516_ HSAEL 521_ PPPDQ 526_ PSPCK 531_ CTCKK 536_ EPSSV 541_ SPSAT 546_ VKTRS 551_ TKAPP 556_ PHLPL 561_ SPALT 566_ RAVEG 571_ VQYIA 576_ DHLKA 581_ EDTDF 586_ SVKED 591_ WKYVA 596_ MVIDR 601_ IFLWM 606_ FIIVC 611_ LLGTV 616_ GLFLP 621_PWLAG
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (PubMed:16835356, PubMed:22361591, PubMed:27698419, PubMed:29720657, PubMed:38454578). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (PubMed:27698419, PubMed:29720657, PubMed:38454578). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity)