26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
1_MEEIG 6_ ILVEK 11_ AQDEI 16_ PALSV 21_ SRPQT 26_ GLSFL 31_ GPEPE 36_ DLEDL 41_ YSRYK 46_ KLQQE 51_ LEFLE 56_ VQEEY 61_ IKDEQ 66_ KNLKK 71_ EFLHA 76_ QEEVK 81_ RIQSI 86_ PLVIG 91_ QFLEA 96_ VDQNT 101_ AIVGS 106_ TTGSN 111_ YYVRI 116_ LSTID 121_ RELLK 126_ PNASV 131_ ALHKH 136_ SNALV 141_ DVLPP 146_ EADSS 151_ IMMLT 156_ SDQKP 161_ DVMYA 166_ DIGGM 171_ DIQKQ 176_ EVREA 181_ VELPL 186_ THFEL 191_ YKQIG 196_ IDPPR 201_ GVLMY 206_ GPPGC 211_ GKTML 216_ AKAVA 221_ HHTTA 226_ AFIRV 231_ VGSEF 236_ VQKYL 241_ GEGPR 246_ MVRDV 251_ FRLAK 256_ ENAPA 261_ IIFID 266_ EIDAI 271_ ATKRF 276_ DAQTG 281_ ADREV 286_ QRILL 291_ ELLNQ 296_ MDGFD 301_ QNVNV 306_ KVIMA 311_ TNRAD 316_ TLDPA 321_ LLRPG 326_ RLDRK 331_ IEFPL 336_ PDRRQ 341_ KRLIF 346_ STITS 351_ KMNLS 356_ EEVDL 361_ EDYVA 366_ RPDKI 371_ SGADI 376_ NSICQ 381_ ESGML 386_ AVREN 391_ RYIVL 396_ AKDFE 401_ KAYKT 406_ VIKKD 411_EQEHE
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides