Transcription factor GATA-4 (GATA-binding factor 4)
1_MYQSL 6_ AMAAN 11_ HGPPP 16_ GAYEA 21_ GGPGA 26_ FMHGA 31_ GAASS 36_ PVYVP 41_ TPRVP 46_ SSVLG 51_ LSYLQ 56_ GGGAG 61_ SASGG 66_ ASGGS 71_ SGGAA 76_ SGAGP 81_ GTQQG 86_ SPGWS 91_ QAGAD 96_ GAAYT 101_ PPPVS 106_ PRFSF 111_ PGTTG 116_ SLAAA 121_ AAAAA 126_ AREAA 131_ AYSSG 136_ GGAAG 141_ AGLAG 146_ REQYG 151_ RAGFA 156_ GSYSS 161_ PYPAY 166_ MADVG 171_ ASWAA 176_ AAAAS 181_ AGPFD 186_ SPVLH 191_ SLPGR 196_ ANPAA 201_ RHPNL 206_ DMFDD 211_ FSEGR 216_ ECVNC 221_ GAMST 226_ PLWRR 231_ DGTGH 236_ YLCNA 241_ CGLYH 246_ KMNGI 251_ NRPLI 256_ KPQRR 261_ LSASR 266_ RVGLS 271_ CANCQ 276_ TTTTT 281_ LWRRN 286_ AEGEP 291_ VCNAC 296_ GLYMK 301_ LHGVP 306_ RPLAM 311_ RKEGI 316_ QTRKR 321_ KPKNL 326_ NKSKT 331_ PAAPS 336_ GSESL 341_ PPASG 346_ ASSNS 351_ SNATT 356_ SSSEE 361_ MRPIK 366_ TEPGL 371_ SSHYG 376_ HSSSV 381_ SQTFS 386_ VSAMS 391_ GHGPS 396_ IHPVL 401_ SALKL 406_ SPQGY 411_ ASPVS 416_ QSPQT 421_ SSKQD 426_ SWNSL 431_ VLADS 436_HGDII
1: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735)