Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)
1_MSMSP 6_ KHTTP 11_ FSVSD 16_ ILSPL 21_ EESYK 26_ KVGME 31_ GGGLG 36_ APLAA 41_ YRQGQ 46_ AAPPT 51_ AAMQQ 56_ HAVGH 61_ HGAVT 66_ AAYHM 71_ TAAGV 76_ PQLSH 81_ SAVGG 86_ YCNGN 91_ LGNMS 96_ ELPPY 101_ QDTMR 106_ NSASG 111_ PGWYG 116_ ANPDP 121_ RFPAI 126_ SRFMG 131_ PASGM 136_ NMSGM 141_ GGLGS 146_ LGDVS 151_ KNMAP 156_ LPSAP 161_ RRKRR 166_ VLFSQ 171_ AQVYE 176_ LERRF 181_ KQQKY 186_ LSAPE 191_ REHLA 196_ SMIHL 201_ TPTQV 206_ KIWFQ 211_ NHRYK 216_ MKRQA 221_ KDKAA 226_ QQQLQ 231_ QDSGG 236_ GGGGG 241_ GTGCP 246_ QQQQA 251_ QQQSP 256_ RRVAV 261_ PVLVK 266_ DGKPC 271_ QAGAP 276_ APGAA 281_ SLQGH 286_ AQQQA 291_ QHQAQ 296_ AAQAA 301_ AAAIS 306_ VGSGG 311_ AGLGA 316_ HPGHQ 321_ PGSAG 326_ QSPDL 331_ AHHAA 336_ SPAAL 341_ QGQVS 346_ SLSHL 351_ NSSGS 356_ DYGTM 361_ SCSTL 366_LYGRT
1: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity)