Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)
1_MHPGV 6_ LAAFL 11_ FLSWT 16_ HCRAL 21_ PLPSG 26_ GDEDD 31_ LSEED 36_ LQFAE 41_ RYLRS 46_ YYHPT 51_ NLAGI 56_ LKENA 61_ ASSMT 66_ ERLRE 71_ MQSFF 76_ GLEVT 81_ GKLDD 86_ NTLDV 91_ MKKPR 96_ CGVPD 101_ VGEYN 106_ VFPRT 111_ LKWSK 116_ MNLTY 121_ RIVNY 126_ TPDMT 131_ HSEVE 136_ KAFKK 141_ AFKVW 146_ SDVTP 151_ LNFTR 156_ LHDGI 161_ ADIMI 166_ SFGIK 171_ EHGDF 176_ YPFDG 181_ PSGLL 186_ AHAFP 191_ PGPNY 196_ GGDAH 201_ FDDDE 206_ TWTSS 211_ SKGYN 216_ LFLVA 221_ AHEFG 226_ HSLGL 231_ DHSKD 236_ PGALM 241_ FPIYT 246_ YTGKS 251_ HFMLP 256_ DDDVQ 261_ GIQSL 266_ YGPGD 271_ EDPNP 276_ KHPKT 281_ PDKCD 286_ PSLSL 291_ DAITS 296_ LRGET 301_ MIFKD 306_ RFFWR 311_ LHPQQ 316_ VDAEL 321_ FLTKS 326_ FWPEL 331_ PNRID 336_ AAYEH 341_ PSHDL 346_ IFIFR 351_ GRKFW 356_ ALNGY 361_ DILEG 366_ YPKKI 371_ SELGL 376_ PKEVK 381_ KISAA 386_ VHFED 391_ TGKTL 396_ LFSGN 401_ QVWRY 406_ DDTNH 411_ IMDKD 416_ YPRLI 421_ EEDFP 426_ GIGDK 431_ VDAVY 436_ EKNGY 441_ IYFFN 446_ GPIQF 451_ EYSIW 456_ SNRIV 461_ RVMPA 466_NSILW
1: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion