ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) (ATP-binding cassette transporter 8) (White protein homolog)
1_MACLM 6_ AAFSV 11_ GTAMN 16_ ASSYS 21_ AEMTE 26_ PKSVC 31_ VSVDE 36_ VVSSN 41_ MEATE 46_ TDLLN 51_ GHLKK 56_ VDNNL 61_ TEAQR 66_ FSSLP 71_ RRAAV 76_ NIEFR 81_ DLSYS 86_ VPEGP 91_ WWRKK 96_ GYKTL 101_ LKGIS 106_ GKFNS 111_ GELVA 116_ IMGPS 121_ GAGKS 126_ TLMNI 131_ LAGYR 136_ ETGMK 141_ GAVLI 146_ NGLPR 151_ DLRCF 156_ RKVSC 161_ YIMQD 166_ DMLLP 171_ HLTVQ 176_ EAMMV 181_ SAHLK 186_ LQEKD 191_ EGRRE 196_ MVKEI 201_ LTALG 206_ LLSCA 211_ NTRTG 216_ SLSGG 221_ QRKRL 226_ AIALE 231_ LVNNP 236_ PVMFF 241_ DEPTS 246_ GLDSA 251_ SCFQV 256_ VSLMK 261_ GLAQG 266_ GRSII 271_ CTIHQ 276_ PSAKL 281_ FELFD 286_ QLYVL 291_ SQGQC 296_ VYRGK 301_ VCNLV 306_ PYLRD 311_ LGLNC 316_ PTYHN 321_ PADFV 326_ MEVAS 331_ GEYGD 336_ QNSRL 341_ VRAVR 346_ EGMCD 351_ SDHKR 356_ DLGGD 361_ AEVNP 366_ FLWHR 371_ PSEEV 376_ KQTKR 381_ LKGLR 386_ KDSSS 391_ MEGCH 396_ SFSAS 401_ CLTQF 406_ CILFK 411_ RTFLS 416_ IMRDS 421_ VLTHL 426_ RITSH 431_ IGIGL 436_ LIGLL 441_ YLGIG 446_ NEAKK 451_ VLSNS 456_ GFLFF 461_ SMLFL 466_ MFAAL 471_ MPTVL 476_ TFPLE 481_ MGVFL 486_ REHLN 491_ YWYSL 496_ KAYYL 501_ AKTMA 506_ DVPFQ 511_ IMFPV 516_ AYCSI 521_ VYWMT 526_ SQPSD 531_ AVRFV 536_ LFAAL 541_ GTMTS 546_ LVAQS 551_ LGLLI 556_ GAAST 561_ SLQVA 566_ TFVGP 571_ VTAIP 576_ VLLFS 581_ GFFVS 586_ FDTIP 591_ TYLQW 596_ MSYIS 601_ YVRYG 606_ FEGVI 611_ LSIYG 616_ LDRED 621_ LHCDI 626_ DETCH 631_ FQKSE 636_ AILRE 641_ LDVEN 646_ AKLYL 651_ DFIVL 656_ GIFFI 661_ SLRLI 666_ AYFVL 671_RYKIR
1: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620)