Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
1_MATHG 6_ QTCAR 11_ PMCIP 16_ PSYAD 21_ LGKAA 26_ RDIFN 31_ KGFGF 36_ GLVKL 41_ DVKTK 46_ SCSGV 51_ EFSTS 56_ GSSNT 61_ DTGKV 66_ TGTLE 71_ TKYKW 76_ CEYGL 81_ TFTEK 86_ WNTDN 91_ TLGTE 96_ IAIED 101_ QICQG 106_ LKLTF 111_ DTTFS 116_ PNTGK 121_ KSGKI 126_ KSSYK 131_ RECIN 136_ LGCDV 141_ DFDFA 146_ GPAIH 151_ GSAVF 156_ GYEGW 161_ LAGYQ 166_ MTFDS 171_ AKSKL 176_ TRNNF 181_ AVGYR 186_ TGDFQ 191_ LHTNV 196_ NDGTE 201_ FGGSI 206_ YQKVC 211_ EDLDT 216_ SVNLA 221_ WTSGT 226_ NCTRF 231_ GIAAK 236_ YQLDP 241_ TASIS 246_ AKVNN 251_ SSLIG 256_ VGYTQ 261_ TLRPG 266_ VKLTL 271_ SALVD 276_ GKSIN 281_ AGGHK 286_VGLAL
1: Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432)
2: Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids