Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)
1_MEGLA 6_ VRLLR 11_ GSRLL 16_ RRNFL 21_ TCLSS 26_ WKIPP 31_ HVSKS 36_ SQSEA 41_ LLNIT 46_ NNGIH 51_ FAPLQ 56_ TFTDE 61_ EMMIK 66_ SSVKK 71_ FAQEQ 76_ IAPLV 81_ STMDE 86_ NSKME 91_ KSVIQ 96_ GLFQQ 101_ GLMGI 106_ EVDPE 111_ YGGTG 116_ ASFLS 121_ TVLVI 126_ EELAK 131_ VDASV 136_ AVFCE 141_ IQNTL 146_ INTLI 151_ RKHGT 156_ EEQKA 161_ TYLPQ 166_ LTTEK 171_ VGSFC 176_ LSEAG 181_ AGSDS 186_ FALKT 191_ RADKE 196_ GDYYV 201_ LNGSK 206_ MWISS 211_ AEHAG 216_ LFLVM 221_ ANVDP 226_ TIGYK 231_ GITSF 236_ LVDRD 241_ TPGLH 246_ IGKPE 251_ NKLGL 256_ RASST 261_ CPLTF 266_ ENVKV 271_ PEANI 276_ LGQIG 281_ HGYKY 286_ AIGSL 291_ NEGRI 296_ GIAAQ 301_ MLGLA 306_ QGCFD 311_ YTIPY 316_ IKERI 321_ QFGKR 326_ LFDFQ 331_ GLQHQ 336_ VAHVA 341_ TQLEA 346_ ARLLT 351_ YNAAR 356_ LLEAG 361_ KPFIK 366_ EASMA 371_ KYYAS 376_ EIAGQ 381_ TTSKC 386_ IEWMG 391_ GVGYT 396_ KDYPV 401_ EKYFR 406_ DAKIG 411_ TIYEG 416_ ASNIQ 421_ LNTIA 426_KHIDA
1: Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the removal of one hydrogen from C-2 and C-3 of the fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:10832746, PubMed:11013134, PubMed:21430231, PubMed:7698750). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (PubMed:10832746, PubMed:11013134, PubMed:21430231, PubMed:7698750). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (PubMed:10832746, PubMed:11013134). Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691)