Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
1_MGKKT 6_ KRTAD 11_ SSSSE 16_ DEEEY 21_ VVEKV 26_ LDRRV 31_ VKGQV 36_ EYLLK 41_ WKGFS 46_ EEHNT 51_ WEPEK 56_ NLDCP 61_ ELISE 66_ FMKKY 71_ KKMKE 76_ GENNK 81_ PREKS 86_ ESNKR 91_ KSNFS 96_ NSADD 101_ IKSKK 106_ KREQS 111_ NDIAR 116_ GFERG 121_ LEPEK 126_ IIGAT 131_ DSCGD 136_ LMFLM 141_ KWKDT 146_ DEADL 151_ VLAKE 156_ ANVKC 161_ PQIVI 166_ AFYEE 171_ RLTWH 176_ AYPED 181_ AENKE 186_KETAK
1: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385)