Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
1_MAELS 6_ EEALL 11_ SVLPT 16_ IRVPK 21_ AGDRV 26_ HKDEC 31_ AFSFD 36_ TPESE 41_ GGLYI 46_ CMNTF 51_ LGFGK 56_ QYVER 61_ HFNKT 66_ GQRVY 71_ LHLRR 76_ TRRPK 81_ EEDPA 86_ TGTGD 91_ PPRKK 96_ PTRLA 101_ IGVEG 106_ GFDLS 111_ EEKFE 116_ LDEDV 121_ KIVIL 126_ PDYLE 131_ IARDG 136_ LGGLP 141_ DIVRD 146_ RVTSA 151_ VEALL 156_ SADSA 161_ SRKQE 166_ VQAWD 171_ GEVRQ 176_ VSKHA 181_ FSLKQ 186_ LDNPA 191_ RIPPC 196_ GWKCS 201_ KCDMR 206_ ENLWL 211_ NLTDG 216_ SILCG 221_ RRYFD 226_ GSGGN 231_ NHAVE 236_ HYRET 241_ GYPLA 246_ VKLGT 251_ ITPDG 256_ ADVYS 261_ YDEDD 266_ MVLDP 271_ SLAEH 276_ LSHFG 281_ IDMLK 286_ MQKTD 291_ KTMTE 296_ LEIDM 301_ NQRIG 306_ EWELI 311_ QESGV 316_ PLKPL 321_ FGPGY 326_ TGIRN 331_ LGNSC 336_ YLNSV 341_ VQVLF 346_ SIPDF 351_ QRKYV 356_ DKLEK 361_ IFQNA 366_ PTDPT 371_ QDFST 376_ QVAKL 381_ GHGLL 386_ SGEYS 391_ KPVPE 396_ SGDGE 401_ RVPEQ 406_ KEVQD 411_ GIAPR 416_ MFKAL 421_ IGKGH 426_ PEFST 431_ NRQQD 436_ AQEFF 441_ LHLIN 446_ MVERN 451_ CRSSE 456_ NPNEV 461_ FRFLV 466_ EEKIK 471_ CLATE 476_ KVKYT 481_ QRVDY 486_ IMQLP 491_ VPMDA 496_ ALNKE 501_ ELLEY 506_ EEKKR 511_ QAEEE 516_ KMALP 521_ ELVRA 526_ QVPFS 531_ SCLEA 536_ YGAPE 541_ QVDDF 546_ WSTAL 551_ QAKSV 556_ AVKTT 561_ RFASF 566_ PDYLV 571_ IQIKK 576_ FTFGL 581_ DWVPK 586_ KLDVS 591_ IEMPE 596_ ELDIS 601_ QLRGT 606_ GLQPG 611_ EEELP 616_ DIAPP 621_ LVTPD 626_ EPKGS 631_ LGFYG 636_ NEDED 641_ SFCSP 646_ HFSSP 651_ TSPML 656_ DESVI 661_ IQLVE 666_ MGFPM 671_ DACRK 676_ AVYYT 681_ GNSGA 686_ EAAMN 691_ WVMSH 696_ MDDPD 701_ FANPL 706_ ILPGS 711_ SGPGS 716_ TSAAA 721_ DPPPE 726_ DCVTT 731_ IVSMG 736_ FSRDQ 741_ ALKAL 746_ RATNN 751_ SLERA 756_ VDWIF 761_ SHIDD 766_ LDAEA 771_ AMDIS 776_ EGRSA 781_ ADSIS 786_ ESVPV 791_ GPKVR 796_ DGPGK 801_ YQLFA 806_ FISHM 811_ GTSTM 816_ CGHYV 821_ CHIKK 826_ EGRWV 831_ IYNDQ 836_ KVCAS 841_ EKPPK 846_ DLGYI 851_YFYQR
1: Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter (PubMed:26912724). Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains (PubMed:29567855). Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein (PubMed:37534934). Affects T-cell biology by stabilizing the inhibitory receptor on T-cells PDC1 (PubMed:37208329). Acts as a negative regulator of autophagy by regulating ULK1 at both protein and mRNA levels (PubMed:37607937). Acts also as a negative regulator of type I interferon production by simultaneously removing both 'Lys-48'-linked unanchored and 'Lys-63'-linked anchored polyubiquitin chains on the transcription factor IRF3 (PubMed:39761299). Modulates the stability of DNA mismatch repair protein MLH1 and counteracts the effect of the ubiquitin ligase UBR4 (PubMed:39032648). Upon activation by insulin, it gets phosphorylated through mTORC1-mediated phosphorylation to enhance YTHDF1 stability by removing 'Lys-11'-linked polyubiquitination (PubMed:39900921). May also deubiquitinate other substrates such as the calcium channel CACNA1H (By similarity)