Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
1_MWPTR 6_ RLVTI 11_ KRSGV 16_ DGPHF 21_ PLSLS 26_ TCLFG 31_ RGIEC 36_ DIRIQ 41_ LPVVS 46_ KQHCK 51_ IEIHE 56_ QEAIL 61_ HNFSS 66_ TNPTQ 71_ VNGSV 76_ IDEPV 81_ RLKHG 86_ DVITI 91_ IDRSF 96_ RYENE 101_ SLQNG 106_ RKSTE 111_ FPRKI 116_ REQEP 121_ ARRVS 126_ RSSFS 131_ SDPDE 136_ KAQDS 141_ KAYSK 146_ ITEGK 151_ VSGNP 156_ QVHIK 161_ NVKED 166_ STADD 171_ SKDSV 176_ AQGTT 181_ NVHSS 186_ EHAGR 191_ NGRNA 196_ ADPIS 201_ GDFKE 206_ ISSVK 211_ LVSRY 216_ GELKS 221_ VPTTQ 226_ CLDNS 231_ KKNES 236_ PFWKL 241_ YESVK 246_ KELDV 251_ KSQKE 256_ NVLQY 261_ CRKSG 266_ LQTDY 271_ ATEKE 276_ SADGL 281_ QGETQ 286_ LLVSR 291_ KSRPK 296_ SGGSG 301_ HAVAE 306_ PASPE 311_ QELDQ 316_ NKGKG 321_ RDVES 326_ VQTPS 331_ KAVGA 336_ SFPLY 341_ EPAKM 346_ KTPVQ 351_ YSQQQ 356_ NSPQK 361_ HKNKD 366_ LYTTG 371_ RRESV 376_ NLGKS 381_ EGFKA 386_ GDKTL 391_ TPRKL 396_ STRNR 401_ TPAKV 406_ EDAAD 411_ SATKP 416_ ENLSS 421_ KTRGS 426_ IPTDV 431_ EVLPT 436_ ETEIH 441_ NEPFL 446_ TLWLT 451_ QVERK 456_ IQKDS 461_ LSKPE 466_ KLGTT 471_ AGQMC 476_ SGLPG 481_ LSSVD 486_ INNFG 491_ DSINE 496_ SEGIP 501_ LKRRR 506_ VSFGG 511_ HLRPE 516_ LFDEN 521_ LPPNT 526_ PLKRG 531_ EAPTK 536_ RKSLV 541_ MHTPP 546_ VLKKI 551_ IKEQP 556_ QPSGK 561_ QESGS 566_ EIHVE 571_ VKAQS 576_ LVISP 581_ PAPSP 586_ RKTPV 591_ ASDQR 596_ RRSCK 601_ TAPAS 606_ SSKSQ 611_ TEVPK 616_ RGGRK 621_ SGNLP 626_ SKRVS 631_ ISRSQ 636_ HDILQ 641_ MICSK 646_ RRSGA 651_ SEANL 656_ IVAKS 661_ WADVV 666_ KLGAK 671_ QTQTK 676_ VIKHG 681_ PQRSM 686_ NKRQR 691_ RPATP 696_ KKPVG 701_ EVHSQ 706_ FSTGH 711_ ANSPC 716_ TIIIG 721_ KAHTE 726_ KVHVP 731_ ARPYR 736_ VLNNF 741_ ISNQK 746_ MDFKE 751_ DLSGI 756_ AEMFK 761_ TPVKE 766_ QPQLT 771_ STCHI 776_ AISNS 781_ ENLLG 786_ KQFQG 791_ TDSGE 796_ EPLLP 801_ TSESF 806_ GGNVF 811_ FSAQN 816_ AAKQP 821_ SDKCS 826_ ASPPL 831_ RRQCI 836_ RENGN 841_ VAKTP 846_ RNTYK 851_ MTSLE 856_ TKTSD 861_ TETEP 866_ SKTVS 871_ TANRS 876_ GRSTE 881_ FRNIQ 886_ KLPVE 891_ SKSEE 896_ TNTEI 901_ VECIL 906_ KRGQK 911_ ATLLQ 916_ QRREG 921_ EMKEI 926_ ERPFE 931_ TYKEN 936_ IELKE 941_ NDEKM 946_ KAMKR 951_ SRTWG 956_ QKCAP 961_ MSDLT 966_ DLKSL 971_ PDTEL 976_ MKDTA 981_ RGQNL 986_ LQTQD 991_ HAKAP 996_ KSEKG 1001_ KITKM 1006_ PCQSL 1011_ QPEPI 1016_ NTPTH 1021_ TKQQL 1026_ KASLG 1031_ KVGVK 1036_ EELLA 1041_ VGKFT 1046_ RTSGE 1051_ TTHTH 1056_ REPAG 1061_ DGKSI 1066_ RTFKE 1071_ SPKQI 1076_ LDPAA 1081_ RVTGM 1086_ KKWPR 1091_ TPKEE 1096_ AQSLE 1101_ DLAGF 1106_ KELFQ 1111_ TPGPS 1116_ EESMT 1121_ DEKTT 1126_ KIACK 1131_ SPPPE 1136_ SVDTP 1141_ TSTKQ 1146_ WPKRS 1151_ LRKAD 1156_ VEEEF 1161_ LALRK 1166_ LTPSA 1171_ GKAML 1176_ TPKPA 1181_ GGDEK 1186_ DIKAF 1191_ MGTPV 1196_ QKLDL 1201_ AGTLP 1206_ GSKRQ 1211_ LQTPK 1216_ EKAQA 1221_ LEDLA 1226_ GFKEL 1231_ FQTPG 1236_ HTEEL 1241_ VAAGK 1246_ TTKIP 1251_ CDSPQ 1256_ SDPVD 1261_ TPTST 1266_ KQRPK 1271_ RSIRK 1276_ ADVEG 1281_ ELLAC 1286_ RNLMP 1291_ SAGKA 1296_ MHTPK 1301_ PSVGE 1306_ EKDII 1311_ IFVGT 1316_ PVQKL 1321_ DLTEN 1326_ LTGSK 1331_ RRPQT 1336_ PKEEA 1341_ QALED 1346_ LTGFK 1351_ ELFQT 1356_ PGHTE 1361_ EAVAA 1366_ GKTTK 1371_ MPCES 1376_ SPPES 1381_ ADTPT 1386_ STRRQ 1391_ PKTPL 1396_ EKRDV 1401_ QKELS 1406_ ALKKL 1411_ TQTSG 1416_ ETTHT 1421_ DKVPG 1426_ GEDKS 1431_ INAFR 1436_ ETAKQ 1441_ KLDPA 1446_ ASVTG 1451_ SKRHP 1456_ KTKEK 1461_ AQPLE 1466_ DLAGL 1471_ KELFQ 1476_ TPVCT 1481_ DKPTT 1486_ HEKTT 1491_ KIACR 1496_ SQPDP 1501_ VDTPT 1506_ SSKPQ 1511_ SKRSL 1516_ RKVDV 1521_ EEEFF 1526_ ALRKR 1531_ TPSAG 1536_ KAMHT 1541_ PKPAV 1546_ SGEKN 1551_ IYAFM 1556_ GTPVQ 1561_ KLDLT 1566_ ENLTG 1571_ SKRRL 1576_ QTPKE 1581_ KAQAL 1586_ EDLAG 1591_ FKELF 1596_ QTRGH 1601_ TEESM 1606_ TNDKT 1611_ AKVAC 1616_ KSSQP 1621_ DPDKN 1626_ PASSK 1631_ RRLKT 1636_ SLGKV 1641_ GVKEE 1646_ LLAVG 1651_ KLTQT 1656_ SGETT 1661_ HTHTE 1666_ PTGDG 1671_ KSMKA 1676_ FMESP 1681_ KQILD 1686_ SAASL 1691_ TGSKR 1696_ QLRTP 1701_ KGKSE 1706_ VPEDL 1711_ AGFIE 1716_ LFQTP 1721_ SHTKE 1726_ SMTNE 1731_ KTTKV 1736_ SYRAS 1741_ QPDLV 1746_ DTPTS 1751_ SKPQP 1756_ KRSLR 1761_ KADTE 1766_ EEFLA 1771_ FRKQT 1776_ PSAGK 1781_ AMHTP 1786_ KPAVG 1791_ EEKDI 1796_ NTFLG 1801_ TPVQK 1806_ LDQPG 1811_ NLPGS 1816_ NRRLQ 1821_ TRKEK 1826_ AQALE 1831_ ELTGF 1836_ RELFQ 1841_ TPCTD 1846_ NPTTD 1851_ EKTTK 1856_ KILCK 1861_ SPQSD 1866_ PADTP 1871_ TNTKQ 1876_ RPKRS 1881_ LKKAD 1886_ VEEEF 1891_ LAFRK 1896_ LTPSA 1901_ GKAMH 1906_ TPKAA 1911_ VGEEK 1916_ DINTF 1921_ VGTPV 1926_ EKLDL 1931_ LGNLP 1936_ GSKRR 1941_ PQTPK 1946_ EKAKA 1951_ LEDLA 1956_ GFKEL 1961_ FQTPG 1966_ HTEES 1971_ MTDDK 1976_ ITEVS 1981_ CKSPQ 1986_ PDPVK 1991_ TPTSS 1996_ KQRLK 2001_ ISLGK 2006_ VGVKE 2011_ EVLPV 2016_ GKLTQ 2021_ TSGKT 2026_ TQTHR 2031_ ETAGD 2036_ GKSIK 2041_ AFKES 2046_ AKQML 2051_ DPANY 2056_ GTGME 2061_ RWPRT 2066_ PKEEA 2071_ QSLED 2076_ LAGFK 2081_ ELFQT 2086_ PDHTE 2091_ ESTTD 2096_ DKTTK 2101_ IACKS 2106_ PPPES 2111_ MDTPT 2116_ STRRR 2121_ PKTPL 2126_ GKRDI 2131_ VEELS 2136_ ALKQL 2141_ TQTTH 2146_ TDKVP 2151_ GDEDK 2156_ GINVF 2161_ RETAK 2166_ QKLDP 2171_ AASVT 2176_ GSKRQ 2181_ PRTPK 2186_ GKAQP 2191_ LEDLA 2196_ GLKEL 2201_ FQTPI 2206_ CTDKP 2211_ TTHEK 2216_ TTKIA 2221_ CRSPQ 2226_ PDPVG 2231_ TPTIF 2236_ KPQSK 2241_ RSLRK 2246_ ADVEE 2251_ ESLAL 2256_ RKRTP 2261_ SVGKA 2266_ MDTPK 2271_ PAGGD 2276_ EKDMK 2281_ AFMGT 2286_ PVQKL 2291_ DLPGN 2296_ LPGSK 2301_ RWPQT 2306_ PKEKA 2311_ QALED 2316_ LAGFK 2321_ ELFQT 2326_ PGTDK 2331_ PTTDE 2336_ KTTKI 2341_ ACKSP 2346_ QPDPV 2351_ DTPAS 2356_ TKQRP 2361_ KRNLR 2366_ KADVE 2371_ EEFLA 2376_ LRKRT 2381_ PSAGK 2386_ AMDTP 2391_ KPAVS 2396_ DEKNI 2401_ NTFVE 2406_ TPVQK 2411_ LDLLG 2416_ NLPGS 2421_ KRQPQ 2426_ TPKEK 2431_ AEALE 2436_ DLVGF 2441_ KELFQ 2446_ TPGHT 2451_ EESMT 2456_ DDKIT 2461_ EVSCK 2466_ SPQPE 2471_ SFKTS 2476_ RSSKQ 2481_ RLKIP 2486_ LVKVD 2491_ MKEEP 2496_ LAVSK 2501_ LTRTS 2506_ GETTQ 2511_ THTEP 2516_ TGDSK 2521_ SIKAF 2526_ KESPK 2531_ QILDP 2536_ AASVT 2541_ GSRRQ 2546_ LRTRK 2551_ EKARA 2556_ LEDLV 2561_ DFKEL 2566_ FSAPG 2571_ HTEES 2576_ MTIDK 2581_ NTKIP 2586_ CKSPP 2591_ PELTD 2596_ TATST 2601_ KRCPK 2606_ TRPRK 2611_ EVKEE 2616_ LSAVE 2621_ RLTQT 2626_ SGQST 2631_ HTHKE 2636_ PASGD 2641_ EGIKV 2646_ LKQRA 2651_ KKKPN 2656_ PVEEE 2661_ PSRRR 2666_ PRAPK 2671_ EKAQP 2676_ LEDLA 2681_ GFTEL 2686_ SETSG 2691_ HTQES 2696_ LTAGK 2701_ ATKIP 2706_ CESPP 2711_ LEVVD 2716_ TTAST 2721_ KRHLR 2726_ TRVQK 2731_ VQVKE 2736_ EPSAV 2741_ KFTQT 2746_ SGETT 2751_ DADKE 2756_ PAGED 2761_ KGIKA 2766_ LKESA 2771_ KQTPA 2776_ PAASV 2781_ TGSRR 2786_ RPRAP 2791_ RESAQ 2796_ AIEDL 2801_ AGFKD 2806_ PAAGH 2811_ TEESM 2816_ TDDKT 2821_ TKIPC 2826_ KSSPE 2831_ LEDTA 2836_ TSSKR 2841_ RPRTR 2846_ AQKVE 2851_ VKEEL 2856_ LAVGK 2861_ LTQTS 2866_ GETTH 2871_ TDKEP 2876_ VGEGK 2881_ GTKAF 2886_ KQPAK 2891_ RKLDA 2896_ EDVIG 2901_ SRRQP 2906_ RAPKE 2911_ KAQPL 2916_ EDLAS 2921_ FQELS 2926_ QTPGH 2931_ TEELA 2936_ NGAAD 2941_ SFTSA 2946_ PKQTP 2951_ DSGKP 2956_ LKISR 2961_ RVLRA 2966_ PKVEP 2971_ VGDVV 2976_ STRDP 2981_ VKSQS 2986_ KSNTS 2991_ LPPLP 2996_ FKRGG 3001_ GKDGS 3006_ VTGTK 3011_ RLRCM 3016_ PAPEE 3021_ IVEEL 3026_ PASKK 3031_ QRVAP 3036_ RARGK 3041_ SSEPV 3046_ VIMKR 3051_ SLRTS 3056_ AKRIE 3061_ PAEEL 3066_ NSNDM 3071_ KTNKE 3076_ EHKLQ 3081_ DSVPE 3086_ NKGIS 3091_ LRSRR 3096_ QNKTE 3101_ AEQQI 3106_ TEVFV 3111_ LAERI 3116_ EINRN 3121_ EKKPM 3126_ KTSPE 3131_ MDIQN 3136_ PDDGA 3141_ RKPIP 3146_ RDKVT 3151_ ENKRC 3156_ LRSAR 3161_ QNESS 3166_ QPKVA 3171_ EESGG 3176_ QKSAK 3181_ VLMQN 3186_ QKGKG 3191_ EAGNS 3196_ DSMCL 3201_ RSRKT 3206_ KSQPA 3211_ ASTLE 3216_ SKSVQ 3221_ RVTRS 3226_ VKRCA 3231_ ENPKK 3236_ AEDNV 3241_ CVKKI 3246_ RTRSH 3251_RDSED
1: Protein that associates with the surface of mitotic chromosomes and acts both as a chromosome repellent during early mitosis and chromosome attractant during late mitosis (PubMed:27362226, PubMed:32879492, PubMed:35513709, PubMed:39153474). Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). During early mitosis, relocalizes from nucleoli to the chromosome surface where it forms extended brush structures that cover a substantial fraction of the chromosome surface (PubMed:27362226). The MKI67 brush structure prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). During mitotic anaphase, the MKI67 brush structure collapses and MKI67 switches from a chromosome repellent to a chromosome attractant to promote chromosome clustering and facilitate the exclusion of large cytoplasmic particles from the future nuclear space (PubMed:32879492, PubMed:39153474). Mechanistically, dephosphorylation during mitotic exit and simultaneous exposure of a conserved basic patch induce the RNA-dependent formation of a liquid-like condensed phase on the chromosome surface, promoting coalescence of neighboring chromosome surfaces and clustering of chromosomes (PubMed:39153474). Binds premature ribosomal RNAs during anaphase; promoting liquid-liquid phase separation (PubMed:28935370, PubMed:39153474). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization; it is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in mitotic chromosome (PubMed:24867636)