ATP-dependent DNA helicase Q1 (EC 3.6.4.12) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)
1_MASVS 6_ ALTEE 11_ LDSIT 16_ SELHA 21_ VEIQI 26_ QELTE 31_ RQQEL 36_ IQKKK 41_ VLTKK 46_ IKQCL 51_ EDSDA 56_ GASNE 61_ YDSSP 66_ AAWNK 71_ EDFPW 76_ SGKVK 81_ DILQN 86_ VFKLE 91_ KFRPL 96_ QLETI 101_ NVTMA 106_ GKEVF 111_ LVMPT 116_ GGGKS 121_ LCYQL 126_ PALCS 131_ DGFTL 136_ VICPL 141_ ISLME 146_ DQLMV 151_ LKQLG 156_ ISATM 161_ LNASS 166_ SKEHV 171_ KWVHA 176_ EMVNK 181_ NSELK 186_ LIYVT 191_ PEKIA 196_ KSKMF 201_ MSRLE 206_ KAYEA 211_ RRFTR 216_ IAVDE 221_ VHCCS 226_ QWGHD 231_ FRPDY 236_ KALGI 241_ LKRQF 246_ PNASL 251_ IGLTA 256_ TATNH 261_ VLTDA 266_ QKILC 271_ IEKCF 276_ TFTAS 281_ FNRPN 286_ LYYEV 291_ RQKPS 296_ NTEDF 301_ IEDIV 306_ KLING 311_ RYKGQ 316_ SGIIY 321_ CFSQK 326_ DSEQV 331_ TVSLQ 336_ NLGIH 341_ AGAYH 346_ ANLEP 351_ EDKTT 356_ VHRKW 361_ SANEI 366_ QVVVA 371_ TVAFG 376_ MGIDK 381_ PDVRF 386_ VIHHS 391_ MSKSM 396_ ENYYQ 401_ ESGRA 406_ GRDDM 411_ KADCI 416_ LYYGF 421_ GDIFR 426_ ISSMV 431_ VMENV 436_ GQQKL 441_ YEMVS 446_ YCQNI 451_ SKCRR 456_ VLMAQ 461_ HFDEV 466_ WNSEA 471_ CNKMC 476_ DNCCK 481_ DSAFE 486_ RKNIT 491_ EYCRD 496_ LIKIL 501_ KQAEE 506_ LNEKL 511_ TPLKL 516_ IDSWM 521_ GKGAA 526_ KLRVA 531_ GVVAP 536_ TLPRE 541_ DLEKI 546_ IAHFL 551_ IQQYL 556_ KEDYS 561_ FTAYA 566_ TISYL 571_ KIGPK 576_ ANLLN 581_ NEAHA 586_ ITMQV 591_ TKSTQ 596_ NSFRA 601_ ESSQT 606_ CHSEQ 611_ GDKKM 616_ EEKNS 621_ GNFQK 626_ KAANM 631_ LQQSG 636_ SKNTG 641_AKKRK
1: DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:15886194, PubMed:35025765, PubMed:7527136, PubMed:7961977, PubMed:8056767). Exhibits a Mg(2+)- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:19151156, PubMed:35025765, PubMed:7527136, PubMed:8056767). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). Does not unwind G-quadruplex DNA (PubMed:18426915). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:15886194, PubMed:7961977)