Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)
1_MGRKL 6_ DPTKE 11_ KRGPG 16_ RKARK 21_ QKGAE 26_ TELVR 31_ FLPAV 36_ SDENS 41_ KRLSS 46_ RARKR 51_ AAKRR 56_ LGSVE 61_ APKTN 66_ KSPEA 71_ KPLPG 76_ KLPKG 81_ ISAGA 86_ VQTAG 91_ KKGPQ 96_ SLFNA 101_ PRGKK 106_ RPAPG 111_ SDEEE 116_ EEEDS 121_ EEDGM 126_ VNHGD 131_ LWGSE 136_ DDADT 141_ VDDYG 146_ ADSNS 151_ EDEEE 156_ GEALL 161_ PIERA 166_ ARKQK 171_ AREAA 176_ AGIQW 181_ SEEET 186_ EDEEE 191_ EKEVT 196_ PESGP 201_ PKVEE 206_ ADGGL 211_ QINVD 216_ EEPFV 221_ LPPAG 226_ EMEQD 231_ AQAPD 236_ LQRVH 241_ KRIQD 246_ IVGIL 251_ RDFGA 256_ QREEG 261_ RSRSE 266_ YLNRL 271_ KKDLA 276_ IYYSY 281_ GDFLL 286_ GKLMD 291_ LFPLS 296_ ELVEF 301_ LEANE 306_ VPRPV 311_ TLRTN 316_ TLKTR 321_ RRDLA 326_ QALIN 331_ RGVNL 336_ DPLGK 341_ WSKTG 346_ LVVYD 351_ SSVPI 356_ GATPE 361_ YLAGH 366_ YMLQG 371_ ASSML 376_ PVMAL 381_ APQEH 386_ ERILD 391_ MCCAP 396_ GGKTS 401_ YMAQL 406_ MKNTG 411_ VILAN 416_ DANAE 421_ RLKSV 426_ VGNLH 431_ RLGVT 436_ NTIIS 441_ HYDGR 446_ QFPKV 451_ VGGFD 456_ RVLLD 461_ APCSG 466_ TGVIS 471_ KDPAV 476_ KTNKD 481_ EKDIL 486_ RCAHL 491_ QKELL 496_ LSAID 501_ SVNAT 506_ SKTGG 511_ YLVYC 516_ TCSIT 521_ VEENE 526_ WVVDY 531_ ALKKR 536_ NVRLV 541_ PTGLD 546_ FGQEG 551_ FTRFR 556_ ERRFH 561_ PSLRS 566_ TRRFY 571_ PHTHN 576_ MDGFF 581_ IAKFK 586_ KFSNS 591_ IPQSQ 596_ TGNSE 601_ TATPT 606_ NVDLP 611_ QVIPK 616_ SENSS 621_ QPAKK 626_ AKGAA 631_ KTKQQ 636_ LQKQQ 641_ HPKKA 646_ SFQKL 651_ NGISK 656_ GADSE 661_ LSTVP 666_ SVTKT 671_ QASSS 676_ FQDSS 681_ QPAGK 686_ AEGIR 691_ EPKVT 696_ GKLKQ 701_ RSPKL 706_ QSSKK 711_ VAFLR 716_ QNAPP 721_ KGTDT 726_ QTPAV 731_ LSPSK 736_ TQATL 741_ KPKDH 746_ HQPLG 751_ RAKGV 756_ EKQQL 761_ PEQPF 766_ EKAAF 771_ QKQND 776_ TPKGP 781_ QPPTV 786_ SPIRS 791_ SRPPP 796_ AKRKK 801_ SQSRG 806_NSQLL
1: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868)