Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)
1_MEDLE 6_ ETLFE 11_ EFENY 16_ SYDLD 21_ YYSLE 26_ SDLEE 31_ KVQLG 36_ VVHWV 41_ SLVLY 46_ CLAFV 51_ LGIPG 56_ NAIVI 61_ WFTGF 66_ KWKKT 71_ VTTLW 76_ FLNLA 81_ IADFI 86_ FLLFL 91_ PLYIS 96_ YVAMN 101_ FHWPF 106_ GIWLC 111_ KANSF 116_ TAQLN 121_ MFASV 126_ FFLTV 131_ ISLDH 136_ YIHLI 141_ HPVLS 146_ HRHRT 151_ LKNSL 156_ IVIIF 161_ IWLLA 166_ SLIGG 171_ PALYF 176_ RDTVE 181_ FNNHT 186_ LCYNN 191_ FQKHD 196_ PDLTL 201_ IRHHV 206_ LTWVK 211_ FIIGY 216_ LFPLL 221_ TMSIC 226_ YLCLI 231_ FKVKK 236_ RSILI 241_ SSRHF 246_ WTILV 251_ VVVAF 256_ VVCWT 261_ PYHLF 266_ SIWEL 271_ TIHHN 276_ SYSHH 281_ VMQAG 286_ IPLST 291_ GLAFL 296_ NSCLN 301_ PILYV 306_ LISKK 311_ FQARF 316_ RSSVA 321_ EILKY 326_ TLWEV 331_ SCSGT 336_ VSEQL 341_ RNSET 346_KNLCL
1: Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity)
2: (Microbial infection) Coreceptor for HIV-1