Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
1_MTAEP 6_ MSESK 11_ LNTLV 16_ QKLHD 21_ FLAHS 26_ SEESE 31_ ETSSP 36_ PRLAM 41_ NQNTD 46_ KISGS 51_ GSNSD 56_ MMENS 61_ KEEGT 66_ SSSEK 71_ SKSSG 76_ SSRSK 81_ RKPSI 86_ VTKYV 91_ ESDDE 96_ KPLDD 101_ ETVNE 106_ DASNE 111_ NSEND 116_ ITMQS 121_ LPKGT 126_ VIVQP 131_ EPVLN 136_ EDKDD 141_ FKGPE 146_ FRSRS 151_ KMKTE 156_ NLKKR 161_ GEDGL 166_ HGIVS 171_ CTACG 176_ QQVNH 181_ FQKDS 186_ IYRHP 191_ SLQVL 196_ ICKNC 201_ FKYYM 206_ SDDIS 211_ RDSDG 216_ MDEQC 221_ RWCAE 226_ GGNLI 231_ CCDFC 236_ HNAFC 241_ KKCIL 246_ RNLGR 251_ KELST 256_ IMDEN 261_ NQWYC 266_ YICHP 271_ EPLLD 276_ LVTAC 281_ NSVFE 286_ NLEQL 291_ LQQNK 296_ KKIKV 301_ DSEKS 306_ NKVYE 311_ HTSRF 316_ SPKKT 321_ SSNCN 326_ GEEKK 331_ LDDSC 336_ SGSVT 341_ YSYSA 346_ LIVPK 351_ EMIKK 356_ AKKLI 361_ ETTAN 366_ MNSSY 371_ VKFLK 376_ QATDN 381_ SEISS 386_ ATKLR 391_ QLKAF 396_ KSVLA 401_ DIKKA 406_ HLALE 411_ EDLNS 416_ EFRAM 421_ DAVNK 426_ EKNTK 431_ EHKVI 436_ DAKFE 441_ TKARK 446_ GEKPC 451_ ALEKK 456_ DISKS 461_ EAKLS 466_ RKQVD 471_ SEHMH 476_ QNVPT 481_ EEQRT 486_ NKSTG 491_ GEHKK 496_ SDRKE 501_ EPQYE 506_ PANTS 511_ EDLDM 516_ DIVSV 521_ PSSVP 526_ EDIFE 531_ NLETA 536_ MEVQS 541_ SVDHQ 546_ GDGSS 551_ GTEQE 556_ VESSS 561_ VKLNI 566_ SSKDN 571_ RGGIK 576_ SKTTA 581_ KVTKE 586_ LYVKL 591_ TPVSL 596_ SNSPI 601_ KGADC 606_ QEVPQ 611_ DKDGY 616_ KSCGL 621_ NPKLE 626_ KCGLG 631_ QENSD 636_ NEHLV 641_ ENEVS 646_ LLLEE 651_ SDLRR 656_ SPRVK 661_ TTPLR 666_ RPTET 671_ NPVTS 676_ NSDEE 681_ CNETV 686_ KEKQK 691_ LSVPV 696_ RKKDK 701_ RNSSD 706_ SAIDN 711_ PKPNK 716_ LPKSK 721_ QSETV 726_ DQNSD 731_ SDEML 736_ AILKE 741_ VSRMS 746_ HSSSS 751_ DTDIN 756_ EIHTN 761_ HKTLY 766_ DLKTQ 771_ AGKDD 776_ KGKRK 781_ RKSST 786_ SGSDF 791_ DTKKG 796_ KSAKS 801_ SIISK 806_ KKRQT 811_ QSESS 816_ NYDSE 821_ LEKEI 826_ KSMSK 831_ IGAAR 836_ TTKKR 841_ IPNTK 846_ DFDSS 851_ EDEKH 856_ SKKGM 861_ DNQGH 866_ KNLKT 871_ SQEGS 876_ SDDAE 881_ RKQER 886_ ETFSS 891_ AEGTV 896_ DKDTT 901_ IMELR 906_ DRLPK 911_ KQQAS 916_ ASTDG 921_ VDKLS 926_ GKEES 931_ FTSLE 936_ VRKVA 941_ ETKEK 946_ SKHLK 951_ TKTCK 956_ KVQDG 961_ LSDIA 966_ EKFLK 971_ KDQSD 976_ ETSED 981_ DKKQS 986_ KKGTE 991_ EKKKP 996_ SDFKK 1001_ KVIKM 1006_ EQQYE 1011_ SSSDG 1016_ TEKLP 1021_ EREEI 1026_ CHFPK 1031_ GIKQI 1036_ KNGTT 1041_ DGEKK 1046_ SKKIR 1051_ DKTSK 1056_ KKDEL 1061_ SDYAE 1066_ KSTGK 1071_ GDSCD 1076_ SSEDK 1081_ KSKNG 1086_ AYGRE 1091_ KKRCK 1096_ LLGKS 1101_ SRKRQ 1106_ DCSSS 1111_ DTEKY 1116_ SMKED 1121_ GCNSS 1126_ DKRLK 1131_ RIELR 1136_ ERRNL 1141_ SSKRN 1146_ TKEIQ 1151_ SGSSS 1156_ SDAEE 1161_ SSEDN 1166_ KKKKQ 1171_ RTSSK 1176_ KKAVI 1181_ VKEKK 1186_ RNSLR 1191_ TSTKR 1196_ KQADI 1201_ TSSSS 1206_ SDIED 1211_ DDQNS 1216_ IGEGS 1221_ SDEQK 1226_ IKPVT 1231_ ENLVL 1236_ SSHTG 1241_ FCQSS 1246_ GDEAL 1251_ SKSVP 1256_ VTVDD 1261_ DDDDN 1266_ DPENR 1271_ IAKKM 1276_ LLEEI 1281_ KANLS 1286_ SDEDG 1291_ SSDDE 1296_ PEEGK 1301_ KRTGK 1306_ QNEEN 1311_ PGDEE 1316_ AKNQV 1321_ NSESD 1326_ SDSEE 1331_ SKKPR 1336_ YRHRL 1341_ LRHKL 1346_ TVSDG 1351_ ESGEE 1356_ KKTKP 1361_ KEHKE 1366_ VKGRN 1371_ RRKVS 1376_ SEDSE 1381_ DSDFQ 1386_ ESGVS 1391_ EEVSE 1396_ SEDEQ 1401_ RPRTR 1406_ SAKKA 1411_ ELEEN 1416_ QRSYK 1421_ QKKKR 1426_ RRIKV 1431_ QEDSS 1436_ SENKS 1441_ NSEEE 1446_ EEEKE 1451_ EEEEE 1456_ EEEEE 1461_ EEEED 1466_ ENDDS 1471_ KSPGK 1476_ GRKKI 1481_ RKILK 1486_ DDKLR 1491_ TETQN 1496_ ALKEE 1501_ EERRK 1506_ RIAER 1511_ ERERE 1516_ KLREV 1521_ IEIED 1526_ ASPTK 1531_ CPITT 1536_ KLVLD 1541_ EDEET 1546_ KEPLV 1551_ QVHRN 1556_ MVIKL 1561_ KPHQV 1566_ DGVQF 1571_ MWDCC 1576_ CESVK 1581_ KTKKS 1586_ PGSGC 1591_ ILAHC 1596_ MGLGK 1601_ TLQVV 1606_ SFLHT 1611_ VLLCD 1616_ KLDFS 1621_ TALVV 1626_ CPLNT 1631_ ALNWM 1636_ NEFEK 1641_ WQEGL 1646_ KDDEK 1651_ LEVSE 1656_ LATVK 1661_ RPQER 1666_ SYMLQ 1671_ RWQED 1676_ GGVMI 1681_ IGYEM 1686_ YRNLA 1691_ QGRNV 1696_ KSRKL 1701_ KEIFN 1706_ KALVD 1711_ PGPDF 1716_ VVCDE 1721_ GHILK 1726_ NEASA 1731_ VSKAM 1736_ NSIRS 1741_ RRRII 1746_ LTGTP 1751_ LQNNL 1756_ IEYHC 1761_ MVNFI 1766_ KENLL 1771_ GSIKE 1776_ FRNRF 1781_ INPIQ 1786_ NGQCA 1791_ DSTMV 1796_ DVRVM 1801_ KKRAH 1806_ ILYEM 1811_ LAGCV 1816_ QRKDY 1821_ TALTK 1826_ FLPPK 1831_ HEYVL 1836_ AVRMT 1841_ SIQCK 1846_ LYQYY 1851_ LDHLT 1856_ GVGNN 1861_ SEGGR 1866_ GKAGA 1871_ KLFQD 1876_ FQMLS 1881_ RIWTH 1886_ PWCLQ 1891_ LDYIS 1896_ KENKG 1901_ YFDED 1906_ SMDEF 1911_ IASDS 1916_ DETSM 1921_ SLSSD 1926_ DYTKK 1931_ KKKGK 1936_ KGKKD 1941_ SSSSG 1946_ SGSDN 1951_ DVEVI 1956_ KVWNS 1961_ RSRGG 1966_ GEGNV 1971_ DETGN 1976_ NPSVS 1981_ LKLEE 1986_ SKATS 1991_ SSNPS 1996_ SPAPD 2001_ WYKDF 2006_ VTDAD 2011_ AEVLE 2016_ HSGKM 2021_ VLLFE 2026_ ILRMA 2031_ EEIGD 2036_ KVLVF 2041_ SQSLI 2046_ SLDLI 2051_ EDFLE 2056_ LASRE 2061_ KTEDK 2066_ DKPLI 2071_ YKGEG 2076_ KWLRN 2081_ IDYYR 2086_ LDGST 2091_ TAQSR 2096_ KKWAE 2101_ EFNDE 2106_ TNVRG 2111_ RLFII 2116_ STKAG 2121_ SLGIN 2126_ LVAAN 2131_ RVIIF 2136_ DASWN 2141_ PSYDI 2146_ QSIFR 2151_ VYRFG 2156_ QTKPV 2161_ YVYRF 2166_ LAQGT 2171_ MEDKI 2176_ YDRQV 2181_ TKQSL 2186_ SFRVV 2191_ DQQQV 2196_ ERHFT 2201_ MNELT 2206_ ELYTF 2211_ EPDLL 2216_ DDPNS 2221_ EKKKK 2226_ RDTPM 2231_ LPKDT 2236_ ILAEL 2241_ LQIHK 2246_ EHIVG 2251_ YHEHD 2256_ SLLDH 2261_ KEEEE 2266_ LTEEE 2271_ RKAAW 2276_ AEYEA 2281_ EKKGL 2286_ TMRFN 2291_ IPTGT 2296_ NLPPV 2301_ SFNSQ 2306_ TPYIP 2311_ FNLGA 2316_ LSAMS 2321_ NQQLE 2326_ DLINQ 2331_ GREKV 2336_ VEATN 2341_ SVTAV 2346_ RIQPL 2351_ EDIIS 2356_ AVWKE 2361_ NMNLS 2366_ EAQVQ 2371_ ALALS 2376_ RQASQ 2381_ ELDVK 2386_ RREAI 2391_ YNDVL 2396_ TKQQM 2401_ LISCV 2406_ QRILM 2411_ NRRLQ 2416_ QQYNQ 2421_ QQQQQ 2426_ MTYQQ 2431_ ATLGH 2436_ LMMPK 2441_ PPNLI 2446_ MNPSN 2451_ YQQID 2456_ MRGMY 2461_ QPVAG 2466_ GMQPP 2471_ PLQRA 2476_ PPPMR 2481_ SKNPG 2486_PSQGK
1: Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610)