Adapter molecule crk (Proto-oncogene c-Crk) (p38)
1_MAGNF 6_ DSEER 11_ SSWYW 16_ GRLSR 21_ QEAVA 26_ LLQGQ 31_ RHGVF 36_ LVRDS 41_ STSPG 46_ DYVLS 51_ VSENS 56_ RVSHY 61_ IINSS 66_ GPRPP 71_ VPPSP 76_ AQPPP 81_ GVSPS 86_ RLRIG 91_ DQEFD 96_ SLPAL 101_ LEFYK 106_ IHYLD 111_ TTTLI 116_ EPVSR 121_ SRQGS 126_ GVILR 131_ QEEAE 136_ YVRAL 141_ FDFNG 146_ NDEED 151_ LPFKK 156_ GDILR 161_ IRDKP 166_ EEQWW 171_ NAEDS 176_ EGKRG 181_ MIPVP 186_ YVEKY 191_ RPASA 196_ SVSAL 201_ IGGNQ 206_ EGSHP 211_ QPLGG 216_ PEPGP 221_ YAQPS 226_ VNTPL 231_ PNLQN 236_ GPIYA 241_ RVIQK 246_ RVPNA 251_ YDKTA 256_ LALEV 261_ GELVK 266_ VTKIN 271_ VSGQW 276_ EGECN 281_ GKRGH 286_ FPFTH 291_ VRLLD 296_QQNPD
1: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1
2: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity)