Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
1_MSNVR 6_ VSNGS 11_ PSLER 16_ MDARQ 21_ AEHPK 26_ PSACR 31_ NLFGP 36_ VDHEE 41_ LTRDL 46_ EKHCR 51_ DMEEA 56_ SQRKW 61_ NFDFQ 66_ NHKPL 71_ EGKYE 76_ WQEVE 81_ KGSLP 86_ EFYYR 91_ PPRPP 96_ KGACK 101_ VPAQE 106_ SQDVS 111_ GSRPA 116_ APLIG 121_ APANS 126_ EDTHL 131_ VDPKT 136_ DPSDS 141_ QTGLA 146_ EQCAG 151_ IRKRP 156_ ATDDS 161_ STQNK 166_ RANRT 171_ EENVS 176_ DGSPN 181_ AGSVE 186_ QTPKK 191_PGLRR
1: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry